Recombinant Mouse S100A8 Protein (2-89 aa), His-tagged
Cat.No. : | S100A8-1510M |
Product Overview : | Recombinant Mouse S100A8 Protein (2-89 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length of Mature Protein. |
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Description : | S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and Extracellular domain functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assbly at the cell mbrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assbly by directly binding to NCF2/P67PHOX. The Extracellular domain functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 ses to contribute to S-nitrosylation site selectivity. |
Source : | Yeast |
Species : | Mouse |
Tag : | His |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 12.2 kDa |
Protein length : | 2-89 aa |
AA Sequence : | PSELEKALSNLIDVYHNYSNIQGNH HALYKNDFKKMVTTECPQFVQNINI ENLFRELDINSDNAINFEEFLAMVI KVGVASHKDSHKE |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with reconstitution instruction is sent along with the products. |
Gene Name : | S100a8 S100 calcium binding protein A8 (calgranulin A) [ Mus musculus ] |
Official Symbol : | S100A8 |
Synonyms : | S100A8; MRP-8; p8; B8Ag; CFAg; Caga; MRP8; CP-10; 60B8Ag; AI323541; |
Gene ID : | 20201 |
mRNA Refseq : | NM_013650 |
Protein Refseq : | NP_038678 |
UniProt ID : | P27005 |
Products Types
◆ Recombinant Protein | ||
S100A8-294H | Recombinant Human S100A8 Protein, MYC/DDK-tagged | +Inquiry |
S100A8-226H | Recombinant Human S100A8 Protein, MYC/DDK-tagged | +Inquiry |
S100A8-3881R | Recombinant Rhesus Macaque S100A8 Protein, His (Fc)-Avi-tagged | +Inquiry |
S100a8-405M | Recombinant Mouse S100A8 protein(Pro2-Glu89), His-tagged | +Inquiry |
S100A8-4874R | Recombinant Rat S100A8 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
S100A8-685HCL | Recombinant Human S100A8 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewDependable protein quantification, ensures experimental accuracy.
Consistent western blot results, a lab essential.
Expert protein engineering support, essential for our projects.
Q&As (7)
Ask a questionChanges in S100A8 expression impact cellular stress responses, with implications for aging and age-related diseases.
S100A8 contributes to cancer development, influencing tumor cell proliferation and metastatic potential.
S100A8 is involved in wound healing, affecting tissue repair and regeneration.
S100A8 binds calcium ions, modulating inflammatory processes and cytokine production.
S100A8 affects cardiovascular disease development, impacting inflammation and vascular integrity.
S100A8 plays a significant role in the immune response, impacting the pathogenesis of autoimmune diseases.
S100A8 influences skin health, playing a role in maintaining skin barrier function and in skin disorders.
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