| Description : |
Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect. |
| Form : |
Powder, White to off-white |
| Target : |
ROCK |
| In Vitro : |
Y-27632 dihydrochloride (GMP) (2 μM; 4-8 days) increases the survival rate and enhances reprogramming of mouse fibroblasts directly converted into neuronal cells.
Y-27632 dihydrochloride (GMP) induces the conversion of human fibroblasts into functional cardiomyocytes.
Y-27632 dihydrochloride (GMP) induces the conversion of fibroblasts into human induced pluripotent stem cells (hiPSCs).
Y-27632 dihydrochloride (GMP) (2-10 μM) promotes the proliferation of human EPS cells and induces the conversion of primed hPSCs into hEPS cells.
Y-27632 dihydrochloride (GMP) (10 μM) induces human EPS cells derived from blastocysts. |
| Solubility Data : |
H2O: 100 mg/mL (312.25 mM; Need ultrasonic) |
| CAS : |
129830-38-2 |
| Formula : |
C14H23Cl2N3O |
| Molecular Mass : |
320.26 |
| Storage : |
At -20 centigrade, sealed storage, away from moisture and light. |
| Shipping : |
Shipping with dry ice. |
