Active GMP Recombinant Human IL11 Protein
|Product Overview :||Recombinant Human IL11, Pro22-Leu199, was produced in Sf 9 (baculovirus)-derived in an animal component free process under cGMP guidelines.|
- Gene Information
- Related Products
|Source :||Insect cell|
|Form :||Lyophilized from a 0.2 μm filtered solution in PBS and EDTA.|
|Bio-activity :||Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The ED50 for this effect is 0.02-0.12 ng/mL.
The specific activity of recombinant human IL-11 is approximately 1.05 x 10^4 units/μg, which is calibrated against recombinant human IL-11 WHO Standard (NIBSC code: 92/788).
|Molecular Mass :||Predicted Molecular Mass: 19 kDa
SDS-PAGE: 20 kDa, reducing conditions
|N-terminal Sequence Analysis :||Pro-Gly-Pro-Pro-Pro-Gly-Pro-Pro-Arg-Val|
|Endotoxin :||<0.10 EU per 1 μg of the protein by the LAL method.|
|Purity :||>95%, by SDS-PAGE with silver staining, under reducing conditions.|
|Storage :||Avoid repeated freeze-thaw cycles.
12 months, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
|Reconstitution :||Reconstitute at 100 μg/mL in PBS.|
|Quality Statement :||Our GMP proteins are produced according to relevant sections of the following documents: WHO TRS, No. 822, 1992 Annex 1, Good Manufacturing Practices for Biological Products; USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products and USP Chapter 92, Growth Factors and Cytokines Used in Cell Therapy Manufacturing.|
|Shipping :||The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.|
|Gene Name :||IL11 interleukin 11 [ Homo sapiens ]|
|Official Symbol :||IL11|
|Synonyms :||IL11; interleukin 11; interleukin-11; adipogenesis inhibitory factor; AGIF; IL 11; oprelvekin; IL-11;|
|Gene ID :||3589|
|mRNA Refseq :||NM_000641|
|Protein Refseq :||NP_000632|
|UniProt ID :||P20809|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Transgenic mice and knockdown models explore IL11's impact on tissue regeneration.
Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.
Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.
Proteomics identifies IL11-interacting proteins and potential cross-talk partners.
Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.
RNA sequencing uncovers IL11-induced gene expression changes across different cell types.
X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.
Confocal and super-resolution microscopy visualize IL11 localization in tissues.
Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.
CRISPR screening unveils genes and pathways influenced by IL11 signaling.
Customer Reviews (3)Write a review
Potent in bone regeneration models. -
Suitable for cell culture. -
High yield in expression. -
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