Active Human CXCL10 Reference Standard

• Cat.No.: CXCL10-9H

Specification

• Description: Among CXC chemokines, CXCL10 has been identified to play an important role in several endocrinological autoimmune diseases such as Hashimoto"s thyroiditis, Graves"disease and Type 1 diabetes mellitus.
• Species: Human
• Form: Liquid
• Bio-activity: The level of CXCL10 in the serum was quantified using ELISA.
• Usage: For research use only, not for diagnostic or therapeutic use.
• Quality Control Test: Generated from a human serum pool. This lot has been tested by standard laboratory procedures and found to be negative for HIV 1, HIV 2, Hepatitis B and Hepatitis C.
• Storage: Stored at -20 °C, 4 °C for less than seven days, frozen for greater than seven days.
• Concentration: 8.35 ng/ml
• Preservative: 0.1% sodium azide
• Tag: Non

Gene Information

• Gene Name: CXCL10 chemokine (C-X-C motif) ligand 10 [ Homo sapiens ]
• Official Symbol: CXCL10
• Synonyms: CXCL10; chemokine (C-X-C motif) ligand 10; INP10, SCYB10, small inducible cytokine subfamily B (Cys X Cys), member 10; C-X-C motif chemokine 10; C7; crg 2; gIP 10; IFI10; IP 10; mob 1; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
• Gene ID: 3627
• mRNA Refseq: NM_001565
• Protein Refseq: NP_001556
• MIM: 147310
• UniProt ID: P02778
• Chromosome Location: 4q21
• Pathway: CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem
• Function: cAMP-dependent protein kinase regulator activity; chemokine activity; receptor binding

Reviews

07/18/2019

Expertise in protein engineering, invaluable for our laboratory's needs.

03/01/2019

Swift protein characterization services, essential for our research projects.

01/23/2018

High-quality protein-protein interaction assays, integral to our experiments.

Q&As

What are the mechanisms by which CXCL10 modulates the blood-brain barrier and affects neuroinflammatory diseases?

CXCL10 affects the blood-brain barrier, playing a role in neuroinflammatory disorders.

What is the impact of CXCL10 on the pathogenesis of autoimmune diseases, like rheumatoid arthritis and lupus?

CXCL10 plays a role in autoimmune diseases, exacerbating conditions like rheumatoid arthritis and lupus.

What role does CXCL10 play in the tumor microenvironment and cancer metastasis?

In cancer, CXCL10 influences the tumor microenvironment and may contribute to tumor spread and metastasis.

How do alterations in CXCL10 expression or signaling affect the progression of chronic inflammatory conditions?

Changes in CXCL10 expression influence chronic inflammatory diseases, potentially aggravating or modulating disease progression.

How does CXCL10 contribute to the antiviral immune response, particularly in viral hepatitis and HIV infections?

CXCL10 is important in antiviral defense, enhancing immune responses against pathogens like hepatitis viruses and HIV.

How does CXCL10 influence angiogenesis and tissue repair processes?

CXCL10 impacts angiogenesis and is involved in tissue repair and regeneration processes.

How does CXCL10 mediate immune cell recruitment and activation in inflammatory and infectious diseases?

CXCL10 attracts and activates immune cells to sites of inflammation and infection, coordinating the immune response.