Active Recombinant Canine CA9 Protein, Fc-tagged, Alexa Fluor 488 conjugated

Cat.No. : CA9-1544CAF488
Product Overview : Alexa Fluor 488 conjugated recombinant canine CA9 (Met1-Leu410) was expressed in human HEK 293 cells and fused with the Fc region of human IgG1 at the C-terminus.
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
Source : HEK293
Species : Dog
Tag : Fc
Form : Lyophilized Powder
Bio-activity : Measured by its esterase activity. The specific activity is > 10 pmoles/min/ μg.
Molecular Mass : The recombinant canine CA9/Fc is a disulfide-linked homodimer. The reduced monomer comprises 614 amino acids and has a predicted molecular mass of 67.6 kDa. The apparent molecular mass of the protein is approximately 79 kDa in SDS-PAGE under reducing conditions.
Protein length : 614
Endotoxin : < 1.0 EU/ μg protein as determined by the LAL method.
Purity : > 99 % as determined by SDS-PAGE
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 488 via amines
Excitation Wavelength: 488 nm
Emission Wavelength: 515­-545 nm
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : 25 mM Tris, 0.15 M NaCl, pH 7.5
Gene Name : CA9 carbonic anhydrase 9 [ Canis lupus familiaris (dog) ]
Official Symbol : CA9
Synonyms : CA9; carbonic anhydrase 9
Gene ID : 611933
mRNA Refseq : NM_001145174
Protein Refseq : NP_001138646
UniProt ID : E2RAI4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What signaling pathways are known to regulate CA9 expression? 06/15/2022

The HIF-1 signaling pathway primarily regulates CA9 in response to cellular oxygen levels.

How does CA9 contribute to pH regulation within the tumor microenvironment? 02/02/2022

CA9 aids in extracellular acidification, promoting tumor cell survival and invasion in acidic tumor microenvironments.

How is CA9 expression regulated in hypoxic conditions? 04/15/2021

CA9 expression is upregulated by the hypoxia-inducible factor (HIF) under low oxygen conditions.

How are elevated levels of CA9 associated with cancer prognosis? 05/26/2020

Elevated CA9 levels often correlate with poor prognosis in various cancers due to its role in tumor adaptation to hypoxia.

What post-translational modifications have been identified on CA9? 11/23/2017

Potential modifications like glycosylation can be identified using techniques like mass spectrometry.

Are there specific inhibitors that target CA9, especially in cancer therapeutics? 09/29/2017

Several inhibitors, like acetazolamide derivatives, have been explored to target CA9 in cancer treatment.

What roles does CA9 play in tumor physiology? 07/06/2017

CA9 helps tumors survive in hypoxic conditions by regulating pH through the conversion of CO2 to bicarbonate and protons.

Customer Reviews (3)

Write a review
Reviews
08/04/2022

    Exceptional consistency, vital for our research's reliability.

    12/16/2021

      Critical support for our protein analysis and quantification.

      02/07/2021

        Unmatched accuracy in protein identification and sequencing.

        Ask a Question for All CA9 Products

        Required fields are marked with *

        My Review for All CA9 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends