Active Recombinant Canine CA9 Protein, His-tagged, FITC conjugated
Cat.No. : | CA9-1039CF |
Product Overview : | FITC conjugated recombinant canine CA9 (NP_001138646.1) (Met1-Leu410) was expressed with a C-terminal polyhistidine tag. |
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Source : | HEK293 |
Species : | Dog |
Tag : | His |
Form : | Lyophilized |
Bio-activity : | Measured by its esterase activity. The specific activity is > 100 pmoles/min/ μg. |
Molecular Mass : | The recombinant canine CA9 comprises 384 amino acids and has a predicted molecular mass of 42.1 kDa. The apparent molecular mass of the protein is approximately 50 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
Protein length : | 384 |
N-terminal Sequence Analysis : | Gln 38 |
Endotoxin : | < 1.0 EU/ μg of the protein as determined by the LAL method. |
Purity : | > 85 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with FITC via amines Excitation source: 488 nm spectral line, argon-ion laser Excitation Wavelength: 488 nm Emission Wavelength: 535 nm |
Stability : | Samples are stable for up to 12 months from date of receipt at -70 centigrade. |
Storage : | Store it under sterile conditions at -20 to-70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4, 5%-8% trehalose and mannitol. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | CA9 carbonic anhydrase IX [ Canis lupus familiaris ] |
Official Symbol : | CA9 |
Synonyms : | carbonic anhydrase 9; |
Gene ID : | 611933 |
mRNA Refseq : | NM_001145174 |
Protein Refseq : | NP_001138646 |
Products Types
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◆ Lysates | ||
CA9-1447CCL | Recombinant Canine CA9 cell lysate | +Inquiry |
CA9-3065HCL | Recombinant Human CA9 cell lysate | +Inquiry |
CA9-2189MCL | Recombinant Mouse CA9 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionThe HIF-1 signaling pathway primarily regulates CA9 in response to cellular oxygen levels.
CA9 aids in extracellular acidification, promoting tumor cell survival and invasion in acidic tumor microenvironments.
CA9 expression is upregulated by the hypoxia-inducible factor (HIF) under low oxygen conditions.
Elevated CA9 levels often correlate with poor prognosis in various cancers due to its role in tumor adaptation to hypoxia.
Potential modifications like glycosylation can be identified using techniques like mass spectrometry.
Several inhibitors, like acetazolamide derivatives, have been explored to target CA9 in cancer treatment.
CA9 helps tumors survive in hypoxic conditions by regulating pH through the conversion of CO2 to bicarbonate and protons.
Customer Reviews (3)
Write a reviewExceptional consistency, vital for our research's reliability.
Critical support for our protein analysis and quantification.
Unmatched accuracy in protein identification and sequencing.
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