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Active Recombinant Dog ACE2 Protein, Fc-tagged

Cat.No. : ACE2-602D
Product Overview : Recombinant Dog ACE2 Protein (18-739) was expressed in CHO cells using a C-terminal Fc tag.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.
Source : CHO
Species : Dog
Tag : Fc
Bio-activity : Binding ability measured in a functional ELISA. Unlike human ACE2, Dog ACE2(18-739) Protein dose not bind well to immobilized 2019-nCoV Spike Protein RBD.
Molecular Mass : ~150 kDa
Protein length : 18-739
Purity : >90 %
Stability : One year at -70 centigrade from date of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot targets into smaller quantities after centrifugation and store at the recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 1.0 μg/μL
Storage Buffer : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 90mM glycine.
Shipping : On dry ice.
Gene Name : ACE2 angiotensin converting enzyme 2 [ Canis lupus familiaris (dog) ]
Official Symbol : ACE2
Synonyms : ACE2; angiotensin converting enzyme 2; angiotensin-converting enzyme 2; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; EC 3.4.17.23
Gene ID : 480847
mRNA Refseq : NM_001165260
Protein Refseq : NP_001158732
UniProt ID : C7ECV0

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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