Active Recombinant Full Length Dog HDAC11 Protein, N-GST-tagged

• Cat.No.: HDAC11-37DFL
• Product Overview: Recombinant full-length dog HDAC11 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: HDAC11 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC11 belongs to class IV of the histone deacetylase family that localizes to the nucleus and is involved in regulating the expression of interleukin 10 (1). HDAC11 expression is the highest in brain, heart, skeletal muscle, kidney and testis. HDAC11 control the DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression. HDAC11 has HDAC activity and this activity is inhibitable by trapoxin, an HDAC inhibitor (2). In coimmunoprecipitation experiments, HDAC11 interacts with HDA6.
• Source: Insect cells
• Species: Dog
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mMDTT, 25% glycerol.
• Bio-activity: 34 RLU/min/ng
• Molecular Mass: Observed MW ~66 kDa.
  Calculated MW ~65 kDa.
• Purity: >90%
• Stability: lyr at -70 centigrade from date of shipment.
• Storage: Store product at -70 centigrade.For optimal storage, aliquot target in to smaller quantities after centrifugation and store at recommended temperature. For most favorable performance,avoid repeated handling and multiplefreeze/thaw cycles.
• Concentration: 0.1 ug/ul

Gene Information

• Gene Name: HDAC11 histone deacetylase 11 [ Canis lupus familiaris (dog) ]
• Official Symbol: HDAC11
• Synonyms: FLJ22237;HD11
• Gene ID: 484633
• mRNA Refseq: XM_038426810.1
• Protein Refseq: XP_038282738.1
• UniProt ID: A0A8P0NXA6