Active Recombinant Human HDAC11 protein, His-tagged

• Cat.No.: HDAC11-32H
• Product Overview: Recombinant Human HDAC11 fused with His tag at N-terminal was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Form: Liquid. In 50mM TRIS, pH 8.0, containing 138mM NaCl and 10% glycerol.
• Bio-activity: Hydrolysis of N-ε-acetyl-lysine residues of histones. ≥2U/µg. One unit is defined as the amount of enzyme that deacetylates 1 pmol/min of FLUOR DE LYS®-SIRT1 substrate at 37 centigrade / 500µM.
• Molecular Mass: ~39 kDa
• Applications: Useful for studies of enzyme kinetics, modulator activity, drug discovery.
• Stability: Stable on ice for approx. 1h. Snap freezing in liquid nitrogen is recommended if refreezing of remaining, undiluted enzyme is necessary. Freezing and storage of diluted enzyme is not recommended.
• Storage: Store at -80 centigrade. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: HDAC11 histone deacetylase 11 [ Homo sapiens ]
• Official Symbol: HDAC11
• Synonyms: HDAC11; histone deacetylase 11; HD11; FLJ22237
• Gene ID: 79885
• mRNA Refseq: NM_024827
• Protein Refseq: NP_079103
• MIM: 607226
• UniProt ID: Q96DB2
• Chromosome Location: 3p25.1
• Pathway: NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH1, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; transcription factor binding