Active Recombinant Full Length Human BTK Protein, Flag tagged

• Cat.No.: BTK-20HFL
• Product Overview: Recombinant human BTK protein was expressed in a baculovirus expression system as the full length protein (accession number NP_000052.1) with an N-terminal FLAG tag.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag
• Protein Length: 1-659 aa
• Description: The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Form: Recombinant BTK protein is in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCI, 10% glycerol, 0.04% Triton X-100 and 0.5mM TCEP.
• Molecular Mass: 77.6 kDa
• Purity: ≥ 95%
• Applications: Recombinant BTK protein is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
• Concentration: 0.5 μg/μL

Gene Information

• Gene Name: BTK Bruton tyrosine kinase [ Homo sapiens (human) ]
• Official Symbol: BTK
• Synonyms: BTK; Bruton tyrosine kinase; AT; ATK; BPK; XLA; IMD1; AGMX1; IGHD3; PSCTK1; tyrosine-protein kinase BTK; B-cell progenitor kinase; Bruton agammaglobulinemia tyrosine kinase; Bruton's tyrosine kinase; agammaglobulinaemia tyrosine kinase; dominant-negative kinase-deficient Brutons tyrosine kinase; EC 2.7.10.2
• Gene ID: 695
• mRNA Refseq: NM_000061
• Protein Refseq: NP_000052
• MIM: 300300
• UniProt ID: B2RAW1