Active Recombinant Full Length Human GSK3A Protein, GST-tagged

Cat.No. : GSK3A-9932HF
Product Overview : Full-length human GSK3α [1-483(end) amino acids of accession number NP_063937.2] was expressed as N-terminal GST-fusion protein (78 kDa) using baculovirus expression system. GST-GSK3α was purified by using glutathione sepharose chromatography.
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Source : Insect (sf21)
Species : Human
Tag : GST
Form : 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
Bio-activity : The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorecence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip™3000.
Protein length : 1-483
Purity : 56%
Applications : SDS-PAGE
Storage : Store at -80C. Avoid repeating freeze-thaws.
Gene Name : glycogen synthase kinase 3 alpha
Official Symbol : GSK3A
Synonyms : GSK3A
Protein Refseq : NP_063937.2
UniProt ID : P49840

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
08/12/2020

    Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.

    09/18/2019

      This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.

      04/10/2019

        the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the GSK3A protein.

        Q&As (5)

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        In what ways is GSK3A linked to diabetes? 09/27/2021

        GSK3A is implicated in insulin signaling and glucose metabolism, and its dysregulation is associated with insulin resistance, a key feature of type 2 diabetes.

        Can GSK3A inhibitors have an impact on mood disorders? 11/16/2019

        Yes, GSK3A is implicated in pathways associated with mood regulation, and inhibitors are being investigated for their potential in treating mood disorders.

        Are there GSK3A modulators being explored for anti-inflammatory therapies? 08/28/2019

        Yes, there is ongoing research to develop GSK3A modulators as potential anti-inflammatory agents.

        How does GSK3A contribute to inflammatory conditions? 04/25/2017

        GSK3A is involved in inflammatory signaling pathways, and its activity is linked to the regulation of inflammatory responses.

        Are there any clinical interventions targeting GSK3A for diabetes management? 04/02/2016

        Researchers are investigating the potential of GSK3A inhibitors to improve insulin sensitivity and glucose homeostasis in diabetes.

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