Active Recombinant Full Length Human RRM2 Protein, C-Flag-tagged

• Cat.No.: RRM2-137HFL
• Product Overview: Recombinant Full Length Human RRM2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Binding assay
• Molecular Mass: 44.7 kDa
• AA Sequence: MLSLRVPLAPITDPQQLQLSPLKGL SLVDKENTPPALSGTRVLASKTARR IFQEPTEPKTKAAAPGVEDE PLLRENPRRFVIFPIEYHDIWQMYK KAEASFWTAEEVDLSKDIQHWESLK PEERYFISHVLAFFAASDGI VNENLVERFSQEVQITEARCFYGFQ IAMENIHSEMYSLLIDTYIKDPKER EFLFNAIETMPCVKKKADWA LRWIGDKEATYGERVVAFAAVEGIF FSGSFASIFWLKKRGLMPGLTFSNE LISRDEGLHCDFACLMFKHL VHKPSEERVREIIINAVRIEQEFLT EALPVKLIGMNCTLMKQYIEFVADR LMLELGFSKVFRVENPFDFM
  ENISLEGKTNFFEKRVGEYQRMGVM SSPTENSFTLDADFTRTRPLEQKLI SEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Glutathione metabolism, Metabolic pathways, p53 signaling pathway, Purine metabolism, Pyrimidine metabolism

Gene Information

• Gene Name: RRM2 ribonucleotide reductase regulatory subunit M2 [ Homo sapiens (human) ]
• Official Symbol: RRM2
• Synonyms: R2; RR2; RR2M; C2orf48
• Gene ID: 6241
• mRNA Refseq: NM_001034.4
• Protein Refseq: NP_001025.1
• MIM: 180390
• UniProt ID: P31350