Active Recombinant Full Length Human SRPK1 Protein, DDK-tagged, Biotinylated

• Cat.No.: SRPK1-5928HF
• Product Overview: Full-length human SRPK1 [1-654(end) amino acids of accession number CAI20544.1] was expressed as N-terminal DYKDDDDK tagged, biotinylated protein (78 kDa) using baculovirus expression system. The protein was purified by using DYKDDDDK tag antibody agarose.

Specification

• Source: Insect (sf21)
• Species: Human
• Tag: DDK
• Form: 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
• Bio-activity: The activity was determined by IMAP™ assay. The enzyme was incubated with fluorescein labeled peptide and phosphorylation was detected by IMAP™ technology (fluorescence polarization).
• Protein length: 1-654(end)
• Purity: 92%
• Applications: SDS-PAGE
• Storage: Store at -80C. Avoid repeating freeze-thaws.

Gene Information

• Gene Name: SRSF protein kinase 1
• Official Symbol: SRPK1
• Synonyms: SRPK1;SFRSK1
• Protein Refseq: CAI20544.1
• UniProt ID: Q96SB4

Reviews

02/02/2023

By using SRPK1 protein, I can gain insights into the underlying molecular processes contributing to amyloidosis, which can ultimately aid in the development of novel therapeutic strategies.

10/17/2022

The manufacturer plays a crucial role in supporting my research with their extensive expertise and resources.

01/01/2022

This assurance enables me to confidently utilize the SRPK1 protein in my research, knowing that it will consistently deliver reliable and accurate results.

Q&As

Can SRPK1 inhibition be used in combination with other cancer treatments?

Combination therapy with SRPK1 inhibitors and other cancer treatments, such as chemotherapy or immunotherapy, is being explored for enhanced efficacy.

How does SRPK1 influence RNA splicing?

SRPK1 phosphorylates SR proteins, which affects their splicing activity and can lead to the inclusion or exclusion of specific exons in mRNA transcripts.

What other diseases or conditions have been linked to SRPK1?

SRPK1 dysregulation has been implicated in neurodegenerative diseases, cardiovascular disorders, and autoimmune conditions.

Are there any known genetic mutations related to SRPK1 and disease susceptibility?

Some genetic variations in the SRPK1 gene have been associated with increased susceptibility to certain diseases, but further research is needed to establish these connections.

How does SRPK1 play a role in RNA processing disorders?

SRPK1 abnormalities can lead to errors in RNA splicing, contributing to RNA processing disorders, such as spinal muscular atrophy and myotonic dystrophy.