Active Recombinant Human AOC3 protein, His-tagged

• Cat.No.: AOC3-564H
• Product Overview: Recombinant Human AOC3(Gly27-Asn763) fused with an N-terminal Met and 10-His tag, followed by a Gly-Gly-Gly-Ser-Gly-Gly-Gly-Ser-Gly-Gly-Gly-Ser-Ile-Glu-Gly-Arg linker, was expressed in Insect cells.

Specification

• Source: Insect cells
• Species: Human
• Tag: His
• Predicted N Terminal: Met
• Form: Supplied as a 0.2 μm filtered solution in HEPES and NaCl.
• Bio-activity: Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is >8 pmol/min/μg.
• Molecular Mass: Predicted Molecular Mass: 85 kDa;SDS-PAGE: 80-90 kDa, reducing conditions.
• Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane.
• Storage: Avoid repeated freeze-thaw cycles.6 months from date of receipt, -20 to -70 centigrade as supplied.3 months, -20 to -70 centigrade under sterile conditions after opening.

Gene Information

• Gene Name: AOC3 amine oxidase, copper containing 3 (vascular adhesion protein 1) [ Homo sapiens ]
• Official Symbol: AOC3
• Synonyms: AOC3; amine oxidase, copper containing 3 (vascular adhesion protein 1); membrane primary amine oxidase; HPAO; VAP 1; VAP1; copper amine oxidase; vascular adhesion protein 1; semicarbazide-sensitive amine oxidase; SSAO; VAP-1
• Gene ID: 8639
• mRNA Refseq: NM_003734
• Protein Refseq: NP_003725
• MIM: 603735
• UniProt ID: Q16853
• Chromosome Location: 17q21
• Pathway: Glycine, serine and threonine metabolism, organism-specific biosystem; Glycine, serine and threonine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Phenylalanine metabolism, organism-specific biosystem; Phenylalanine metabolism, conserved biosystem; Tyrosine metabolism, organism-specific biosystem; Tyrosine metabolism, conserved biosystem
• Function: aliphatic-amine oxidase activity; aminoacetone:oxygen oxidoreductase(deaminating) activity; calcium ion binding; cation channel activity; copper ion binding; copper ion binding; oxidoreductase activity; phenethylamine:oxygen oxidoreductase (deaminating) activity; primary amine oxidase activity; protein homodimerization activity; quinone binding; tryptamine:oxygen oxidoreductase (deaminating) activity

Reviews

07/16/2022

I appreciate the Aoc3 manufacturer's attention to product quality, and their product repeatability is very good, which makes our experiment more smooth.

12/11/2021

Aoc3 can be stored at room temperature for several days without deterioration, which allows us to easily conduct experiments and obtain reliable results.

05/25/2021

Purity is very high, showing good production process and quality control.

04/11/2020

Solubility of Aoc3 demonstrated well in Western blots and can be easily dissolved in a variety of buffers.

Q&As

Is AOC3 suitable for children?

There is no clear data on the use of AOC3 in children, and more research is needed to determine its safety and efficacy.

What is AOC3 used for?

AOC3 is an important enzyme that produces human myocardial peptides, which play a key role in heart function and blood pressure regulation.

Have there been relevant studies showing that AOC3 can improve cardiac function?

Some studies have shown that AOC3 may have a certain improvement in cardiac function, but more clinical trials are needed to verify it.

What are the potential side effects of AOC3 therapy?

It has not been fully determined, but some possible adverse effects include allergic reactions, digestive discomfort and headaches.

Is AOC3 suitable for all patients with cardiovascular disease?

There is no clear data showing that AOC3 is suitable for all patients with cardiovascular disease, and the specific application scope needs further research.

Is the combination of AOC3 with other cardiovascular drugs safe?

There is no clear data showing adverse interactions between AOC3 and other cardiovascular drugs, but it should be used in accordance with doctor's recommendations.

How to treat AOC3 ?

At present, AOC3 therapy is mainly administered by injection.

Can AOC3 be used in the treatment of angina?

AOC3 has certain potential for the treatment of angina pectoris, but the specific effect needs to be further verified.

Is there any research to explore the application of AOC3 in the treatment of pulmonary hypertension?

Yes, some studies have explored the potential of AOC3 in the treatment of pulmonary hypertension, but more research is needed to determine its clinical effect.

How to determine the dose of AOC3 ?

The determination of dosage is usually based on specific study design and treatment goals, and multi-center, large-sample studies are required to determine the optimal dose in clinical practice.

What is the progress of clinical trials on AOC3 ?

Clinical trials of AOC3 are ongoing to evaluate its safety and efficacy in the treatment of different diseases.

How does AOC3 regulate blood pressure?

AOC3 can reduce arterial blood pressure and reduce angiotensin II activity through degradation.

Does AOC3 have potential applications in rehabilitation after myocardial infarction?

There is some evidence that AOC3 may have a certain application prospect in the rehabilitation process after myocardial infarction, but more research is needed to verify its clinical effect.

How long does the therapeutic effect of AOC3 last?

Studies used in the treatment of pulmonary hypertension have shown that the therapeutic effect of AOC3 diminishes over time.

Is there any scientific research on the association between AOC3 and heart disease?

There have been academic studies showing an association between AOC3 and heart disease, and it is involved in angiotensin production, left ventricular hypertrophy and angina pectoris.

How to evaluate the clinical efficacy of AOC3 ?

The clinical efficacy of AOC3 is usually evaluated through multicenter, randomized controlled clinical trials.

Does AOC3 have clinical application?

Yes, AOC3 has the potential to be used in the clinic to treat cardiovascular disease and related diseases such as hypertension.

Are there any AOC3 drugs on the market?

There are currently no commercially available AOC3 drugs, but clinical trials are ongoing.