Active Recombinant Human Bone Morphogenetic Protein 8a

• Cat.No.: BMP8A-587H
• Product Overview: Recombinant Human BMP8Aprotein was expressed in Chinese Hamster Ovary cell line. Ala264-His402.

Specification

• Species: Human
• Source: CHO
• Tag: Non
• Protein Length: 264-402 a.a.
• Description: BMP8A, also known asosteogenic protein 2 (OP-2), was first isolated from a hippocampal library ina screen to identify relatives of BMP-7/OP-1. BMPs are a family ofstructurally and functionally related proteins and represent a subfamily ofthe transforming growth factor β (TGF-β) superfamily. BMPs are involved in awide range of processes including embryogenesis, tissue morphogenesis, cell differentiationand migration, and tumorigenesis. Cellular responses to BMPs are mediated by heterooligomericcomplexes of type I and type II serine/threonine kinase receptors.
• Form: Lyophilized from a0.2 μm filtered solution in HCl.
• N-terminalSequence: Ala264
• Molecular Weight: 15.7 kDa (monomer)
• Activity: Measured by itsability to inhibit the cell growth of DU145 human prostate carcinoma cells. TheED50 for this effect is typically 0.2-1 μg/mL.
• Endotoxin Level: < 1.0EU per 1 μg of the protein by the LAL method.
• SDS-PAGE: 19 kDa,reducing conditions.
• Purity: > 95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 250 μg/mL in 4 mMHCl.
• Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: BMP8A bone morphogeneticprotein 8a [ Homo sapiens ]
• Official Symbol: BMP8A
• Synonyms: BMP8A; bonemorphogenetic protein 8a; bone morphogenetic protein 8A; BMP-8A
• Gene ID: 353500
• mRNA Refseq: NM_181809
• Protein Refseq: NP_861525
• UniProt ID: Q7Z5Y6
• Chromosome Location: 1p35-p32
• Pathway: Hedgehog signalingpathway; TGF-beta signaling pathway
• Function: cytokine activity;growth factor activity