| Species : |
Human |
| Source : |
CHO |
| Tag : |
Non |
| Protein Length : |
264-402 a.a. |
| Description : |
BMP8A, also known asosteogenic protein 2 (OP-2), was first isolated from a hippocampal library ina screen to identify relatives of BMP-7/OP-1. BMPs are a family ofstructurally and functionally related proteins and represent a subfamily ofthe transforming growth factor β (TGF-β) superfamily. BMPs are involved in awide range of processes including embryogenesis, tissue morphogenesis, cell differentiationand migration, and tumorigenesis. Cellular responses to BMPs are mediated by heterooligomericcomplexes of type I and type II serine/threonine kinase receptors. |
| Form : |
Lyophilized from a0.2 μm filtered solution in HCl. |
| N-terminalSequence : |
Ala264 |
| Molecular Weight : |
15.7 kDa (monomer) |
| Activity : |
Measured by itsability to inhibit the cell growth of DU145 human prostate carcinoma cells. TheED50 for this effect is typically 0.2-1 μg/mL. |
| Endotoxin Level : |
< 1.0EU per 1 μg of the protein by the LAL method. |
| SDS-PAGE : |
19 kDa,reducing conditions. |
| Purity : |
> 95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
| Reconstitution : |
250 μg/mL in 4 mMHCl. |
| Storage : |
Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution. |
