Active Recombinant Human BTK protein
Cat.No. : | BTK-26220TH |
Product Overview : | Recombinant Human BTK fused with Proprietary tag at C-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Source : | Insect cells |
Species : | Human |
Form : | 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, 10mM reduced Glutathione, pH 8.0 |
Bio-activity : | >450 U/mg |
Molecular Mass : | 106 kDa |
Unit Definition : | One unit defined as the amount of enzyme that will transfer 1nmol phosphate to Tyr substrate per minute at pH 7.4 and 30 centigrade. |
Applications : | Inhibition Assay |
Storage : | Upon delivery aliquot. Store at -80 centigrade. Avoid freeze / thaw cycle. |
Concentration : | Batch dependent within range: 10 µg at 0.36 - 1 mg/ml |
Gene Name : | BTK Bruton agammaglobulinemia tyrosine kinase [ Homo sapiens ] |
Official Symbol : | BTK |
Synonyms : | BTK; Bruton agammaglobulinemia tyrosine kinase; AGMX1, IMD1; tyrosine-protein kinase BTK; ATK; PSCTK1; XLA; B-cell progenitor kinase; agammaglobulinaemia tyrosine kinase; tyrosine-protein kinase BTK isoform (lacking exon 14); dominant-negative kinase-deficient Brutons tyrosine kinase; AT; BPK; IMD1; AGMX1; MGC126261; MGC126262; |
Gene ID : | 695 |
mRNA Refseq : | NM_000061 |
Protein Refseq : | NP_000052 |
MIM : | 300300 |
UniProt ID : | Q5JY90 |
Chromosome Location : | Xq21.33-q22 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; Class I PI3K signaling events, organism-specific biosystem; |
Function : | ATP binding; ATP binding; identical protein binding; kinase activity; lipid binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
Btk-723M | Recombinant Mouse Btk Protein, MYC/DDK-tagged | +Inquiry |
BTK-2827H | Recombinant Human BTK Protein, MYC/DDK-tagged | +Inquiry |
BTK-06H | Recombinant Human BTK (R562W) Mutant Protein, GST-tagged | +Inquiry |
BTK-0744H | Recombinant Human BTK Protein (M1-S659), GST tagged | +Inquiry |
BTK-4931H | Recombinant Human BTK protein(396-659aa), N/A-tagged | +Inquiry |
◆ Lysates | ||
BTK-001HCL | Recombinant Human BTK cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1569 | BTK Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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