Active Recombinant Human CA9 Protein, His-tagged
Cat.No. : | CA9-854H |
Product Overview : | Recombinant Human CA9 Protein(NP_000090.1) (Ser 27-Ala 146), fused to C-terminal His tag, was expressed in HEK293. |
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Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Bio-activity : | Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC,R&D Systems. The IC50 value is < 12 nM. |
Molecular Mass : | The mature recombinant human Cystatin-C consists of 131 amino acids and predicts a molecular mass of 14.8 kDa. The rh Cystatin-C migrates as approximately 17 kDa band in SDS-PAGE as a result of glycosylation. |
Protein length : | Ser 27-Ala 146 |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE. |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | CA9 carbonic anhydrase IX [ Homo sapiens ] |
Official Symbol : | CA9 |
Synonyms : | CA9; carbonic anhydrase IX; carbonic anhydrase 9; CAIX; carbonic dehydratase; MN; RCC associated protein G250; pMW1; CA-IX; P54/58N; membrane antigen MN; carbonate dehydratase IX; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250; |
Gene ID : | 768 |
mRNA Refseq : | NM_001216 |
Protein Refseq : | NP_001207 |
MIM : | 603179 |
UniProt ID : | Q16790 |
Products Types
◆ Recombinant Protein | ||
CA9-0250H | Recombinant Human CA9 Protein, GST-Tagged | +Inquiry |
CA9-116H | Recombinant Human CA9 Protein, His-tagged | +Inquiry |
CA9-2272H | Recombinant Human CA9 Protein, MYC/DDK-tagged | +Inquiry |
CA9-481H | Recombinant Human CA9 Protein, His (Fc)-Avi-tagged | +Inquiry |
CA9-1450C | Recombinant Cynomolgus CA9 protein, His-tagged | +Inquiry |
◆ Lysates | ||
CA9-2189MCL | Recombinant Mouse CA9 cell lysate | +Inquiry |
CA9-3065HCL | Recombinant Human CA9 cell lysate | +Inquiry |
CA9-1447CCL | Recombinant Canine CA9 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewExceptional consistency, vital for our research's reliability.
Critical support for our protein analysis and quantification.
Unmatched accuracy in protein identification and sequencing.
Q&As (7)
Ask a questionThe HIF-1 signaling pathway primarily regulates CA9 in response to cellular oxygen levels.
CA9 aids in extracellular acidification, promoting tumor cell survival and invasion in acidic tumor microenvironments.
CA9 expression is upregulated by the hypoxia-inducible factor (HIF) under low oxygen conditions.
Elevated CA9 levels often correlate with poor prognosis in various cancers due to its role in tumor adaptation to hypoxia.
Potential modifications like glycosylation can be identified using techniques like mass spectrometry.
Several inhibitors, like acetazolamide derivatives, have been explored to target CA9 in cancer treatment.
CA9 helps tumors survive in hypoxic conditions by regulating pH through the conversion of CO2 to bicarbonate and protons.
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