Active Recombinant Human CADM4, Fc-tagged

Cat.No. : CADM4-651H
Product Overview : The recombinant human NECL4-Fc fusion protein is expressed as a 532-amino acid protein consisting of Pro21 - Ala324 region of NECL4 (UniProt accession #Q8NFZ8) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
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Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free).
Bio-activity : Immobilized NECL4 interact heterophilically with NECL1 and NECL3. Enhances neurite outgrowth of E16-E18 rat embryonic cortical neurons.
Molecular Mass : Calculated molecular mass (kDa): 59.0; Estimated by SDS-PAGE under reducing condition (kDa): 75-85
AA Sequence : PGAGQEVQTENVTVAEGGVAEITCR LHQYDGSIVVIQNPARQTLFFNGTR ALKDERFQLEEFSPRRVRIRLSDA RLEDEGGYFCQLYTEDTHHQIATLT VLVAPENPVVEVREQAVEGGEVELS CLVPRSRPAATLRWYRDRKELKGV SSSQENGKVWSVASTVRFRVDRKDD GGIIICEAQNQALPSGHSKQTQYVL DVQYSPTARIHASQAVVREGDTLV LTCAVTGNPRPNQIRWNRGNESLPE RAEAVGETLTLPGLVSADNGTYTCE ASNKHGHARALYVLVVYDPGAVVE AQTSVPYASTGTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTC VVVDVSHEDPEVKFNWYVDGVEVH NAKTKPREEQYNSTYRVVSVLTVLH QDWLNGKEYKCKVSNKALPAPIEKT ISKAKGQPREPQVYTLPPSREEMT KNQVSLTCLVKGFYPSDIAVEWESN GQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPGK
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >95% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : CADM4 cell adhesion molecule 4 [ Homo sapiens ]
Official Symbol : CADM4
Synonyms : CADM4; cell adhesion molecule 4; IGSF4C, immunoglobulin superfamily, member 4C; Necl 4; nectin like 4; SynCAM4; TSLL2; TSLC1-like 2; nectin-like 4; TSLC1-like protein 2; nectin-like protein 4; immunoglobulin superfamily member 4C; immunoglobulin superfamily, member 4C; NECL4; IGSF4C; Necl-4; synCAM4;
Gene ID : 199731
mRNA Refseq : NM_145296
Protein Refseq : NP_660339
MIM : 609744
UniProt ID : Q8NFZ8
Chromosome Location : 19q13.32

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Why is immunoprecipitation important for studying CADM4-related protein interactions? 02/14/2022

Immunoprecipitation allows the isolation of CADM4 and its binding partners, helping identify proteins that interact with CADM4 and revealing its functional associations.

Can you elaborate on the role of Cadm4 in cell signaling pathways, and how do its interactions impact intracellular signaling cascades? 03/05/2021

Cadm4's interactions extend beyond cell adhesion to impact intracellular signaling pathways. Through its adhesive properties, Cadm4 can initiate signaling events that influence cell proliferation, differentiation, and other cellular processes, making it an integral component of cellular signaling networks.

Can you discuss the molecular structure of Cadm4 and its interactions with other proteins or ligands in cellular adhesion processes? 04/01/2020

Cadm4 has a complex molecular structure involving extracellular domains for adhesion. It interacts with various proteins and ligands, facilitating cell adhesion and signaling.

How does Cadm4's expression change during development, and what are its roles in tissue development and differentiation? 08/17/2019

Cadm4 expression varies during development and contributes to tissue development and cellular differentiation, particularly in the nervous system.

What are the current challenges in developing therapies targeting Cadm4, and what research directions are being explored to overcome these challenges? 10/11/2018

The development of Cadm4-targeted therapies faces challenges related to precision and effectiveness. Ongoing research is focused on refining drug targeting strategies and gaining a deeper understanding of Cadm4's relevance in various disease contexts.

Customer Reviews (3)

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Reviews
05/08/2021

    Reliable recombinant proteins are a must for researchers.

    09/02/2019

      These product simplify our research.

      12/12/2018

        Our lab relies on the product for consistency.

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