Active Recombinant Human CCL7, biotinylated

• Cat.No.: CCL7-132H
• Product Overview: Recombinant human CCL7 is produced in E. coli, biotinylated

Specification

• Description: CCL7, also known as Monocyte Chemotactic Protein-3 (MCP-3), is a secreted chemokine that attracts macrophages, monocytes, and eosinophils during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. In vivo, this protein is a substrate of matrix metalloproteinase 2 (MMP2), an enzyme that degrades components of the extracellular matrix. The gene that encodes CCL7 is part of a cluster of C-C chemokine family members on chromosome 17q. CCL7 binds to CCR1, CCR2, and CCR3 receptors and appears to be an antagonist for the CCR5 receptor.
• Source: E. coli
• Species: Human
• Tag: Biotin
• Form: Lyophilized.
• Bio-activity: EC50 = 1.4-2.6nM determined by migration of recombinant CCR2-expressing cells.
• Molecular Mass: 11.2kDa by Mass Spec
• AA Sequence: QPVGINTSTTCCYRFINKKIPKQRL ESYRRTTSSHCPREAVIFKTKLDKE ICADPTQKWVQDFMKHLDKKTQTPK LKLGSGLNDIFEAQKIEWHE
• Endotoxin: <0.01 EU per 1ug of protein by LAL method.
• Purity: >97% by SDS-PAGE
• Storage: 12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution.
• Reconstitution: Recommended at 100ug/ml in sterile distilled water.

Gene Information

• Gene Name: CCL7 chemokine (C-C motif) ligand 7 [ Homo sapiens ]
• Official Symbol: CCL7
• Synonyms: CCL7; chemokine (C-C motif) ligand 7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7; MGC138463; MGC138465; monocyte chemotactic protein 3; monocyte chemoattractant protein 3; small inducible cytokine A7
• Gene ID: 6354
• mRNA Refseq: NM_006273
• Protein Refseq: NP_006264
• MIM: 158106
• UniProt ID: P80098
• Chromosome Location: 17q11.2-q12
• Pathway: Chemokine signaling pathway; Cytokine-cytokine receptor interaction
• Function: chemokine activity; heparin binding