Active Recombinant Human CCL7, biotinylated
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Cat.No. : | CCL7-132H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant human CCL7 is produced in E. coli, biotinylated |
Description : | CCL7, also known as Monocyte Chemotactic Protein-3 (MCP-3), is a secreted chemokine that attracts macrophages, monocytes, and eosinophils during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. In vivo, this protein is a substrate of matrix metalloproteinase 2 (MMP2), an enzyme that degrades components of the extracellular matrix. The gene that encodes CCL7 is part of a cluster of C-C chemokine family members on chromosome 17q. CCL7 binds to CCR1, CCR2, and CCR3 receptors and appears to be an antagonist for the CCR5 receptor. |
Source : | E. coli |
Species : | Human |
Tag : | Biotin |
Form : | Lyophilized. |
Bio-activity : | EC50 = 1.4-2.6nM determined by migration of recombinant CCR2-expressing cells. |
Molecular Mass : | 11.2kDa by Mass Spec |
AA Sequence : | QPVGINTSTT CCYRFINKKI PKQRLESYRR TTSSHCPREA VIFKTKLDKE ICADPTQKWV QDFMKHLDKK TQTPK LKLGSGLNDIFEAQKIEWHE |
Endotoxin : | <0.01 EU per 1ug of protein by LAL method. |
Purity : | >97% by SDS-PAGE |
Storage : | 12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution. |
Reconstitution : | Recommended at 100ug/ml in sterile distilled water. |
Gene Name : | CCL7 chemokine (C-C motif) ligand 7 [ Homo sapiens ] |
Official Symbol : | CCL7 |
Synonyms : | CCL7; chemokine (C-C motif) ligand 7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7; MGC138463; MGC138465; monocyte chemotactic protein 3; monocyte chemoattractant protein 3; small inducible cytokine A7 |
Gene ID : | 6354 |
mRNA Refseq : | NM_006273 |
Protein Refseq : | NP_006264 |
MIM : | 158106 |
UniProt ID : | P80098 |
Chromosome Location : | 17q11.2-q12 |
Pathway : | Chemokine signaling pathway; Cytokine-cytokine receptor interaction |
Function : | chemokine activity; heparin binding |
◆ Recombinant Protein
CCL7-31H | Recombinant Human CCL7 Protein | +Inquiry |
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CCL7-0643H | Recombinant Human CCL7 Protein, GST-Tagged | +Inquiry |
CCL7-32M | Recombinant Mouse CCL7 Protein | +Inquiry |
Ccl7-002M | Recombinant Mouse Ccl7 Protein | +Inquiry |
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◆ Lysates
CCL7-170HCL | Recombinant Human CCL7 lysate | +Inquiry |
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CCL1CCL11Ccl12CCL13CCL14CCL15CCL16CCL17CCL18CCL19CCL2CCL20CCL21Ccl21cCCL22CCL23CCL24CCL25CCL26CCL27Ccl27aCCL28CCL3CCL3L1Ccl4CCL5Ccl6CCL7CCL8Ccl9CCL4L2Ccl21aCCL4L1CCL3L3Ccl21bCcl27b
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