Active Recombinant Human CCL7, biotinylated

Cat.No. : CCL7-132H
Product Overview : Recombinant human CCL7 is produced in E. coli, biotinylated
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Description : CCL7, also known as Monocyte Chemotactic Protein-3 (MCP-3), is a secreted chemokine that attracts macrophages, monocytes, and eosinophils during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. In vivo, this protein is a substrate of matrix metalloproteinase 2 (MMP2), an enzyme that degrades components of the extracellular matrix. The gene that encodes CCL7 is part of a cluster of C-C chemokine family members on chromosome 17q. CCL7 binds to CCR1, CCR2, and CCR3 receptors and appears to be an antagonist for the CCR5 receptor.
Source : E. coli
Species : Human
Tag : Biotin
Form : Lyophilized.
Bio-activity : EC50 = 1.4-2.6nM determined by migration of recombinant CCR2-expressing cells.
Molecular Mass : 11.2kDa by Mass Spec
AA Sequence : QPVGINTSTTCCYRFINKKIPKQRL ESYRRTTSSHCPREAVIFKTKLDKE ICADPTQKWVQDFMKHLDKKTQTPK LKLGSGLNDIFEAQKIEWHE
Endotoxin : <0.01 EU per 1ug of protein by LAL method.
Purity : >97% by SDS-PAGE
Storage : 12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution.
Reconstitution : Recommended at 100ug/ml in sterile distilled water.
Gene Name : CCL7 chemokine (C-C motif) ligand 7 [ Homo sapiens ]
Official Symbol : CCL7
Synonyms : CCL7; chemokine (C-C motif) ligand 7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7; MGC138463; MGC138465; monocyte chemotactic protein 3; monocyte chemoattractant protein 3; small inducible cytokine A7
Gene ID : 6354
mRNA Refseq : NM_006273
Protein Refseq : NP_006264
MIM : 158106
UniProt ID : P80098
Chromosome Location : 17q11.2-q12
Pathway : Chemokine signaling pathway; Cytokine-cytokine receptor interaction
Function : chemokine activity; heparin binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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