Active Recombinant Human CCL7, biotinylated

Species :	Human
Source :	E.coli
Tag :	Non
Description :	CCL7, also known as Monocyte Chemotactic Protein-3 (MCP-3), is a secreted chemokine that attracts macrophages, monocytes, and eosinophils during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. In vivo, this protein is a substrate of matrix metalloproteinase 2 (MMP2), an enzyme that degrades components of the extracellular matrix. The gene that encodes CCL7 is part of a cluster of C-C chemokine family members on chromosome 17q. CCL7 binds to CCR1, CCR2, and CCR3 receptors and appears to be an antagonist for the CCR5 receptor.
Form :	Lyophilized.
Bio-activity :	EC50 = 1.4-2.6nM determined by migration of recombinant CCR2-expressing cells.
Molecular Mass :	11.2kDa by Mass Spec
AA Sequence :	QPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPK LKLGSGLNDIFEAQKIEWHE
Endotoxin :	<0.01 EU per 1ug of protein by LAL method.
Purity :	>97% by SDS-PAGE
Storage :	12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution.
Reconstitution :	Recommended at 100ug/ml in sterile distilled water.
Conjugation :	Biotin

Gene Name	CCL7 chemokine (C-C motif) ligand 7 [ Homo sapiens ]
Official Symbol	CCL7
Synonyms	CCL7; chemokine (C-C motif) ligand 7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7; MGC138463; MGC138465; monocyte chemotactic protein 3; monocyte chemoattractant protein 3; small inducible cytokine A7
Gene ID	6354
mRNA Refseq	NM_006273
Protein Refseq	NP_006264
MIM	158106
UniProt ID	P80098
Chromosome Location	17q11.2-q12
Pathway	Chemokine signaling pathway; Cytokine-cytokine receptor interaction
Function	chemokine activity; heparin binding