Active Recombinant Human CD2 Homodimer Protein, His&Avi tagged

• Cat.No.: CD2-17H
• Product Overview: CD2 protein dimer contains a CD2 extracellular domain (UniProt# P06729) fused with a proprietary cis-dimer motif followed by a tandem His-Avi tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 25-209 aa
• Description: Human cluster of differentiation 2 (CD2), is a Type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD2 is also known as T-cell surface antigen T11/Leu-5, lymphocyte function-associated antigen-2 (LFA-2), lymphocyte function-associated antigen-3 receptor (LFA-3 receptor), sheep red blood cell receptor (SRBC), CD2 molecule, erythrocyte receptor, and rosette receptor. CD2 contains an extracellular domain with two immunoglobulin-like domains (Ig-like), a transmembrane domain, and a cytoplasmic domain. CD2 is expressed on human T cells and natural killer (NK) cells. CD2 interacts with itself or other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58), to play an important role in mediating cell adhesion and signal transduction. CD2 is expressed in a variety of cancer cells, including T-cell lymphomas and leukemias and is also found in B-cell neoplasms. CD2 expression can serve as a prognostic biomarker for these types of cancer. CD2 is an emerging target of cancer therapeutics.
• Molecular Mass: 62 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for CD2-specific antibody binding assay and BLI for lymphocyte function-associated antigen-3 (LFA-3) ligand protein binding assays. Suggested Applications: SPR for CD2-specific antibody and LFA-3 protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: CD2 CD2 molecule [ Homo sapiens (human) ]
• Official Symbol: CD2
• Synonyms: CD2; CD2 molecule; CD2 antigen (p50), sheep red blood cell receptor, SRBC; T-cell surface antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5; CD2 antigen (p50), sheep red blood cell receptor; T11; SRBC; LFA-2; FLJ46032
• Gene ID: 914
• mRNA Refseq: NM_001767
• Protein Refseq: NP_001758
• MIM: 186990
• UniProt ID: P06729