Active Recombinant Human CD200 Chimera Protein

• Cat.No.: CD200-03H
• Product Overview: Recombinant Human CD200 Chimera Protein was expressed in mouse myeloma cell line

Specification

• Description: This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Mouse myeloma cell line
• Species: Human
• Form: Lyophilized
• Bio-activity: Measured by its binding ability in a functional ELISA. When Recombinant Human CD200 R1 Chimera is immobilized at 2 μg/mL (100 μL/well), the concentration of Recombinant Human CD200 Fc Chimera that produces 50% of the optimal binding response is appoximately 2.5‑15 ng/mL.
• Molecular Mass: 49 kDa (monomer)
• N-terminal Sequence Analysis: No results obtained: Gln31 predicted
• Endotoxin: <0.10 EU per 1 ug of the protein by the LAL method.
• Purity: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 °C as supplied.
  1 month, 2 to 8 °C under sterile conditions after reconstitution.
  3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
• Structure / Form: Disulfide-linked homodimer

Gene Information

• Gene Name: CD200 CD200 molecule [ Homo sapiens (human) ]
• Official Symbol: CD200
• Synonyms: antigen identified by monoclonal MRC OX-2; CD200 antigenMOX1; CD200 molecule; CD200; MOX1; MOX2; MOX2MRC; MRC OX-2 antigen; MRC; OX-2 membrane glycoprotein; OX-2
• Gene ID: 4345
• mRNA Refseq: NM_001004196.4
• Protein Refseq: NP_001004196.2
• MIM: 155970
• UniProt ID: P41217

Reviews

08/01/2022

Swift protein sequencing, helps identify unknown proteins.

05/04/2022

Great protein crystallization services, key for structural biology.

05/02/2019

Invaluable protein-protein interaction assays, integral for research.

Q&As

How does CD200 contribute to the regulation of bone marrow and hematopoietic stem cell niches?

CD200 regulates bone marrow and hematopoietic environments, supporting stem cell maintenance and differentiation.

How does CD200 influence tumor immune evasion and the tumor microenvironment in cancer?

CD200 contributes to immune evasion in cancers, affecting tumor progression and response to immunotherapy.

What role does CD200 play in the suppression of inflammatory responses in autoimmune diseases?

CD200 plays a role in suppressing inflammatory responses, which is crucial in autoimmune disease management.

What are the effects of CD200 dysregulation on tissue graft rejection and transplant tolerance?

Dysregulation of CD200 affects tissue graft rejection, influencing transplant tolerance and success.

How do alterations in CD200 expression impact the aging process and age-related immune changes?

Changes in CD200 expression impact the aging immune system, affecting age-related immune regulation and function.

What is the impact of CD200 expression on neuroinflammatory processes and neurodegenerative diseases?

CD200 expression influences neuroinflammatory processes, potentially impacting neurodegenerative diseases.

How does CD200 interact with its receptor CD200R, and what are the implications for immune regulation?

CD200 interacts with CD200R to modulate immune responses, promoting immune tolerance and reducing inflammation.