Active Recombinant Human CD80, Fc-tagged, Biotinylated
Cat.No. : | CD80-582H |
Product Overview : | The recombinant human CD80-Fc fusion protein is expressed as a 437 amino acid protein consisting of Val35 - Asn242 region of CD80 (UniProt accession #P33681) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition. |
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Source : | Human cells |
Species : | Human |
Tag : | Fc |
Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule). |
Bio-activity : | Binds to human CD28, CTLA4 and PD-L1 by ELISA using immobilized CD80 protein. Binds to human and mouse PD-L1 in a functional ELISA. Induces IL-2 secretion by Jurkat human acute T cell leukemia cells with an ED50 of 0.05 - 0.2 μg/mL in the presence of PHA. |
Molecular Mass : | Calculated molecular mass 49.5 kDa; estimated by SDS-PAGE under reducing condition 70-75 kDa probably due to glycosylation. |
AA Sequence : | VIHVTKEVKEVATLSCGHNVSVEEL AQTRIYWQKEKKMVLTMMSGDMNIW PEYKNRTIFDITNNLSIVILALRP SDEGTYECVVLKYEKDAFKREHLAE VTLSVKADFPTPSISDFEIPTSNIR RIICSTSGGFPEPHLSWLENGEEL NAINTTVSQDPETELYAVSSKLDFN MTTNHSFMCLIKYGHLRVNQTFNWN TTKQEHFPDNGSTGTHTCPPCPAP ELLGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVL TVLHQDWLNGKEYKCKVSNKALPAP IEKTISKAKGQPREPQVYTLPPSRE EMTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFF LYSKLTVDKSRWQQGNVFSCSVMHE ALHNHYTQKSLSLSPGK |
Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the |
Purity : | >95% judged by SDS-PAGE under reducing condition |
Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
Protein length : | Val35-Asn242 |
Gene Name : | CD80 CD80 molecule [ Homo sapiens ] |
Official Symbol : | CD80 |
Synonyms : | CD80; CD80 molecule; CD28LG, CD28LG1, CD80 antigen (CD28 antigen ligand 1, B7 1 antigen) , CD80 molecule; T-lymphocyte activation antigen CD80; B lymphocyte activation antigen B7; B7 1; B7.1; activation B7-1 antigen; costimulatory factor CD80; CTLA-4 counter-receptor B7.1; B-lymphocyte activation antigen B7; costimulatory molecule variant IgV-CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); B7; BB1; B7-1; LAB7; CD28LG; CD28LG1; |
Gene ID : | 941 |
mRNA Refseq : | NM_005191 |
Protein Refseq : | NP_005182 |
MIM : | 112203 |
UniProt ID : | P33681 |
Chromosome Location : | 3q13.3-q21 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; |
Function : | coreceptor activity; protein binding; receptor activity; |
Products Types
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CD80-0859H | Recombinant Human CD80 Protein | +Inquiry |
◆ Lysates | ||
CD80-2715HCL | Recombinant Human CD80 cell lysate | +Inquiry |
CD80-948CCL | Recombinant Cynomolgus CD80 cell lysate | +Inquiry |
CD80-1767MCL | Recombinant Mouse CD80 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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