cd80
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  • Official Full Name
  • CD80 antigen
  • Background
  • Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by bindin
  • Synonyms
  • CD80; CD80 antigen; B71; Ly53; TSA1; Cd28l; Ly-53; MIC17; T-lymphocyte activation antigen CD80; B7 protein; activation B7-1 antigen; B7; BB1; LAB7; CD28LG; CD28LG1; OTTHUMP00000215214; OTTHUMP00000215215; costimulatory factor CD80; CTLA-4 counter-receptor B7.1; B-lymphocyte activation antigen B7; costimulatory molecule variant IgV-CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
Cat.#:CD80-2021HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80 Protein, His-tagged
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Cat.#:CD80-363HTag:MIgG2a Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80 Protein, MIgG2a Fc-tagged, low endotoxin
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Cat.#:CD80-0859HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD80 Protein
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Cat.#:CD80-0860HTag:His-Flag-StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD80 Protein, His-Flag-StrepII-Tagged
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Cat.#:CD80-0864HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD80 Protein, GST-Tagged
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Cat.#:CD80-216HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CD80 Protein, His-tagged
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Cat.#:CD80-3114HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80 Protein, MYC/DDK-tagged
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Cat.#:CD80-54HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80 Molecule, Fc-Tagged
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Cat.#:Cd80-1705MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse CD80 Antigen
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Cat.#:CD80-10117HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD80, GST-tagged
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Cat.#:CD80-110HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80 Protein, DDK/His-tagged
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Cat.#:CD80-1280HTag:Avi & His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80 protein, Avi & His-tagged, Biotinylated
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Cat.#:CD80-148HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD80, Fc-tagged
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Cat.#:CD80-27510THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human CD80, Fc-tagged
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Cat.#:CD80-558HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human CD80 protein, His/Fc-tagged
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Cat.#:CD80-55HTag:IgG1/Fc
Source (Host):Human 293 cellsSpecies:Human
Product nameRecombinant Human CD80, Fc-tagged
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Cat.#:CD80-560HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human CD80 protein, His-tagged
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Cat.#:CD80-581HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD80, His-tagged, Biotinylated
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Cat.#:CD80-582HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD80, Fc-tagged, Biotinylated
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Cat.#:CD80-583HTag:Fc/Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80 Protein, Fc & Avi-tagged, Biotinylated
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Cat.#:CD80-589HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80, Fc-His tagged
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Cat.#:CD80-590HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80, None tagged
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Cat.#:CD80-591HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80, His tagged
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Cat.#:CD80-616HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD80, MIgG2a Fc-tagged
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Cat.#:CD80-617HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD80, HIgG1 Fc-tagged
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Cat.#:Cd80-5171MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd80, His tagged
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Cat.#:CD80-626MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse CD80, MIgG2a Fc-tagged
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Cat.#:Cd80-6893MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd80 protein, His & GST-tagged
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Cat.#:Cd80-6898MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd80, Fc tagged
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Cat.#:Cd80-1068RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd80 Protein, Fc-tagged
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Cat.#:Cd80-217RTag:Fc Chimera
Source (Host):NSO cellsSpecies:Rat
Product nameRecombinant Rat Cd80, Fc Chimera
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Cat.#:CD80-1213CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD80 Protein, His-tagged
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Cat.#:CD80-137CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD80, Fc tagged
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Cat.#:CD80-274CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey CD80 protein, His-tagged
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Cat.#:CD80-1512RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CD80 Protein, hIgG1-tagged
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Cat.#:CD80-1513RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CD80 Protein, hIgG4-tagged
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Cat.#:CD80-749RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD80 Protein, His-tagged
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Cat.#:CD80-3572CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CD80
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Cat.#:CD80-2715HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD80 cell lysate
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Cat.#:CD80-1767MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD80 cell lysate
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Cat.#:CD80-948CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD80 cell lysate
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Involved Pathway

Cd80 involved in several pathways and played different roles in them. We selected most pathways Cd80 participated on our site, such as Cell adhesion molecules (CAMs), Toll-like receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cd80 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
CLDN19; HLA-G; CD6; CLDNA; CLDN5; CNTN2; MHC1UEA; NLGN2A; PRPSAP2; NRXN1
Toll-like receptor signaling pathway
IFNA21; IL12A; CCL4L1; IFNB; MYD88; MAP3K7; IFNA4; IKBKG; MAPK12B; MAP2K1
Intestinal i
HLA-DRB5; TNFRSF17; CD80; Icosl; CD40LG; TGFB1A; MHC2A; H2-AA; CCR10; CXCL12
ne network for IgA production
ICOS; ICOSLG; IL-15RA; TGFB1; CD86; TNFRSF13B; IL15RA; BMA2; TNFRSF17; AICDA
Type I diabetes mellitus
HLA-DRA; PRF1; HLA-B; PTPRN2; INS; CD28; IL12B; PTPRN; HLA-F; HLA-DQA2
Autoi
IFNA13; GZMB; HLA-DQB1; H2-AA; HLA-C; H2-AB1; Il2; IFNA14; HLA-DRB5; IFNA5
ne thyroid disease
Ifna15; HLA-DQA1; IFNA10; IL4; HLA-DRB3; HLA-DQB1; HLA-DPB1; IFNA16; CD28; HLA-DPA1
Systemic lupus erythematosus
TROVE2; C7; HIST1H2BF; ACTN1; FCGR1A; C1R; HIST1H4A; HIST1H2BB; HIST2H3A; H2-AA
Rheumatoid arthritis
ATP6V1G2; ATP6V0E1; IFNG; TLR2; ACP5; ATP6V1B2; HLA-DRB5; CCL5; ATP6V0B; IL17A
Allograft rejection
Fasl; H2-AB1; HLA-F; Il2; HLA-DMB; CD80; CD40; HLA-E; HLA-DOB; IL10
Graft-versus-host disease
HLA-DMB; PRF1; H2-AA; KLRD1; HLA-G; IL6; HLA-DRB3; Il2; Fasl; IL1B
Viral myocarditis
CD80; CD40LG; CXADR; SGCA; CCND1; CASP9; HLA-DQA2; HLA-DRB5; HLA-DMA; ITGB2L

Protein Function

Cd80 has several biochemical functions, for example, coreceptor activity, protein binding, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cd80 itself. We selected most functions Cd80 had, and list some proteins which have the same functions with Cd80. You can find most of the proteins on our site.
Function
Related Protein
Function coreceptor activity
Related Protein CD8A; CD28; RAMP1; RGMD; ACVR2A; TMIGD2; CD8B; CCR5; RAMP2; PVRL1
Function protein binding
Related Protein SIRT4; PROX1; STAT5B; BCL2L14; WFIKKN1; ABI1; RPL36AL; NRADD; ATP6V0A1; ZNF404
Function virus receptor activity
Related Protein SLC10A1; SCARB2; HAVCR1; ITGAV; SELPLG; PVRL1; DAG1; CCR5; NCAM1; CLEC4M

Interacting Protein

Cd80 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cd80 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cd80.
CTLA4; NGFR; CD28; CD86; CD274

Cd80 Related Articles

Sagiv-Barfi, I; Kohrt, HEK; et al. Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E966-E972(2015).
Garin, EH; Reiser, J; et al. Case series: CTLA4-IgG1 therapy in minimal change disease and focal segmental glomerulosclerosis. PEDIATRIC NEPHROLOGY 30:469-477(2015).

Cd80 Related Gene Family

Immunoglobulins