Active Recombinant Human CDK7 & CCNH & MNAT1 protein, His & His & His-tagged
Cat.No. : | CDK7 & CCNH & MNAT1-2243H |
Product Overview : | Recombinant Human CDK7 & CCNH & MNAT1 protein(P50613 & P51946 & P51948)(Ala2-Phe346 & Tyr2-Leu323 & Asp2-Ser309), fused with His & His & His tag, was expressed in Insect Cells. |
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Source : | Insect Cells |
Species : | Human |
Tag : | His & His & His |
Form : | Supplied as sterile PBS, pH 7.4. |
Bio-activity : | The specific activity is >5 nmol/min/mg using MBP as substrate. |
Molecular Mass : | The recombinant heterotrimer of human CDK7/CCNH/MNAT1 comprises 1032 (364 + 341 + 327) amino acids and has a calculated molecular mass of 118.8 (41.2 + 39.7 + 37.9) kDa. The apparent molecular mass of rh CDK7/CCNH/MNAT1 heterotrimer is approximately 25,38 & 44 kDa respectively in SDS-PAGE under reducing conditions. |
Protein Length : | Ala2-Phe346 & Tyr2-Leu323 & Asp2-Ser309 |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 85 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | CDK7 cyclin-dependent kinase 7 [ Homo sapiens ] |
Official Symbol : | CDK7 |
Synonyms : | CDK7; cyclin-dependent kinase 7; cyclin dependent kinase 7 (homolog of Xenopus MO15 cdk activating kinase) , cyclin dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk activating kinase); CAK; CAK1; CDKN7; MO15; STK1; p39 Mo15; protein kinase; 39 KDa protein kinase; kinase subunit of CAK; CDK-activating kinase 1; serine/threonine kinase stk1; cell division protein kinase 7; serine/threonine protein kinase 1; serine/threonine-protein kinase 1; serine/threonine protein kinase MO15; homolog of Xenopus MO15 Cdk-activating kinase; TFIIH basal transcription factor complex kinase subunit; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); HCAK; p39MO15; |
Gene ID : | 1022 |
mRNA Refseq : | NM_001799 |
Protein Refseq : | NP_001790 |
MIM : | 601955 |
UniProt ID : | P50613 |
Products Types
◆ Recombinant Protein | ||
CDK7/CCNH/MNAT1-279H | Recombinant Human CDK7/CCNH/MNAT1, His-tagged, Active | +Inquiry |
CDK7-566H | Recombinant Human CDK7 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK7-3786H | Recombinant Human CDK7 protein(1-346aa) | +Inquiry |
Cdk7-868M | Recombinant Mouse Cdk7 Protein, MYC/DDK-tagged | +Inquiry |
CDK7-1033H | Recombinant Human CDK7 Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
CDK7-7621HCL | Recombinant Human CDK7 293 Cell Lysate | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionAt present, some drugs have been developed to act on CDK7, including some small molecule inhibitors and antibody drugs. These drugs can inhibit the activity of CDK7 or regulate its expression, thereby treating diseases associated with aberrant expression of CDK7.
Therapeutic strategies for CDK7 include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against CDK7 to inhibit its aberrant activity in tumors, or the regulation of CDK7 expression through gene knockout or overexpression technologies.
The expression of CDK7 is affected by a variety of factors, including transcription factors, epigenetic modifications, and hormones. For example, the E2F transcription factor can promote the transcription of CDK7, while the histone methyltransferase EZH2 can regulate the cell cycle by inhibiting the transcription of CDK7.
Certain biomolecules can be used as molecular markers of CDK7, such as the mRNA or protein of CDK7 detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
The main role of CDK7 in the cell cycle is to activate CDK2 and CDK1, which in turn drive the cell from G1 to S phase and from G2 to M phase. It regulates cell cycle progression by phosphorylating a variety of substrates, including Rb protein and Wee1 kinase.
CDK7 activity can be detected by methods such as phosphowestern blotting, kinase activity assays, and cell cycle analysis. These methods can detect the phosphorylation level and cell cycle distribution of CDK7 to assess its activity status in cells.
Customer Reviews (3)
Write a reviewWe are very satisfied with the performance and quality of their products and will continue to buy them.
It has high catalysis, high safety and high expression level, which makes the experimental process more convenient and saves a lot of time for scientific research.
The fluorescence and absorption properties are very good.
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