Species : |
Human |
Source : |
E.coli |
Protein Length : |
2-200 a.a. |
Description : |
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. |
Bio-activity : |
Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of TF-1 cells is less than 3.0 ng/mL. |
Molecular Mass : |
22.8 kDa |
Product-Related Proteins : |
2-200 |
Endotoxin : |
< 0.1 EU/μg of the protein as determined by the LAL method |
Purity : |
> 95 % as determined by SDS-PAGE |
Storage : |
At -80 centigrade. Avoid repeated freeze-thaw cycles. |
Storage Buffer : |
PBS |