Active Recombinant Human CSF2RA Homodimer Protein, His&Avi tagged

• Cat.No.: CSF2RA-34H
• Product Overview: CSF2RA dimer protein contains a CSF2RA extracellular domain (UniProt# P15509) fused with a proprietary cis-dimer motif followed by a tandem His-Avi tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 23-320 aa
• Description: Human colony stimulating factor 2 receptor subunit alpha (CSF2RA) is a Type I transmembrane glycoprotein. CSF2RA is also known as granulocyte-macrophage colony-stimulating factor receptor alpha (GMCSFR-alpha), GMRα subunit, and cluster of differentiation 116 (CD116). The CSF2RA extracellular domain contains two fibronectin type III (FN III) domains with a highly conserved WSXWS motif that is present near the C-terminus of the second domain. CSF2RA is expressed on (cell types). CSF2RA is primarily located on neutrophils, eosinophils and monocytes/macrophages and is a receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF). CSF2RA can form a heterodimer with CSF2RB and these heterodimers can form several multimers including a dodecamer. It has been found that CSF2RA specifically has tumor suppression characteristics that have made stimulating CSF2RA expression an emerging strategy in cancer therapy.
• Molecular Mass: 89 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for CSF2RA-specific antibody and ELISA and SPR for granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand protein binding assays. Suggested Applications: SPR & BLI for CSF2RA-specific antibody and BLI for GM-CSF protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [ Homo sapiens (human) ]
• Official Symbol: CSF2RA
• Synonyms: CSF2RA; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CSF2R; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; CD116; GMR-alpha; GMCSFR-alpha; CD116 antigen; GM-CSF receptor alpha subunit; colony stimulating factor 2 receptor alpha subunit; granulocyte-macrophage colony-stimulating factor receptor alpha chain; GMR; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; MGC3848; MGC4838; GM-CSF-R-alpha
• Gene ID: 1438
• mRNA Refseq: NM_001161529
• Protein Refseq: NP_001155001
• MIM: 306250
• UniProt ID: P15509