Active Recombinant Human Growth Differentiation Factor 1
| Cat.No. : | GDF1-717H |
| Product Overview : | Recombinant Human GDF1protein was expressed in CHO. Asp254-Arg372. |
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| Species : | Human |
| Source : | CHO |
| Tag : | Non |
| Protein Length : | 254-372 a.a. |
| Description : | GDF1 is a 12-15 kDasecreted protein in the TGFβ superfamily. It is the functional equivalent offrog, zebrafish, and chick Vg1. Human GDF1 is synthesized as a preproproteinthat contains a 29 amino acid (aa) signal peptide, a 224 aa propeptide, and a119 aa mature peptide which is released following proteolysis at a dibasic cleavagesite. Mature human GDF1 shares 81% aa sequence identity with mouse and ratGDF1. GDF1 is expressed in the developing and adult nervous system,particularly in neurons of the cerebral cortex and hippocampus. |
| Form : | Lyophilized from a0.2 μm filtered solution in HCl with BSA as a carrier protein. |
| N-terminalSequence : | Asp254 |
| Molecular Weight : | 12.6 kDa |
| Activity : | Measuredby its ability to induce Smad2 phosphorylation in P19 mouse embryonalcarcinoma cells. Mazerbourg, S. et al. (2004) Mol. Endocrinol. 18:653. 50ng/mL of Recombinant Human GDF1 can effectively induce Smad2 phosphorylation. |
| Endotoxin Level : | <1.0 EUper 1 μg of the protein by the LAL method. |
| SDS-PAGE : | 13 kDa,reducing conditions. |
| Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
| Reconstitution : | 100μg/mL in 4 mM HCl that containing at least 0.1% human or bovine serum albumin. |
| Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution. |
| Gene Name | GDF1 growth differentiationfactor 1 [ Homo sapiens ] |
| Official Symbol | GDF1 |
| Synonyms | GDF1; growthdifferentiation factor 1; DORV; DTGA3; embryonic growth/differentiationfactor 1; GDF-1 |
| Gene ID | 2657 |
| mRNA Refseq | NM_001492 |
| Protein Refseq | NP_001483 |
| MIM | 602880 |
| UniProt ID | P27539 |
| Chromosome Location | 19p13.11 |
| Pathway | Developmental Biology; Signaling by NODAL |
| Function | cytokine activity; growth factor activity |
Not For Human Consumption!
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