Active Recombinant Human HDAC10, GST-tagged

• Cat.No.: HDAC10-1354H
• Product Overview: Recombinant human HDAC10 (1-482) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: HDAC10 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC10 belongs to class II of the histone deacetylase family that catalyzes the deacetylation of lysine residues in the N-terminal tail of histones and represses transcription in large multiprotein complexes with transcriptional co-repressors. Therefore, HDAC10 plays a role in transcriptional repression. HDAC10 interacts with HDAC3 in co-transfected embryonic kidney cells. Deletion analysis indicates that both the N- and C-terminal domains of HDAC10 bound HDAC3 independently.
• Source: Sf9 Cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 120 RLU/min/ng
• Molecular Mass: ~77 kDa
• Protein length: 1-482 aa
• Purity: >80%
• Applications: HDAC Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: HDAC10 histone deacetylase 10 [ Homo sapiens ]
• Official Symbol: HDAC10
• Synonyms: HDAC10; histone deacetylase 10; DKFZP761B039; HD10; MGC149722; DKFZp761B039
• Gene ID: 83933
• mRNA Refseq: NM_001159286
• Protein Refseq: NP_001152758
• MIM: 608544
• UniProt ID: Q969S8
• Chromosome Location: 22q13.31
• Pathway: NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH1, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); enzyme binding; histone deacetylase activity; histone deacetylase activity (H3-K16 specific); histone deacetylase binding; hydrolase activity; protein binding; protein deacetylase activity

Reviews

08/31/2020

it has demonstrated remarkable effectiveness in ELISA experiments, showcasing its reliability and accuracy in detecting and quantifying specific targets.

06/26/2019

The reliable performance of the HDAC10 protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

09/12/2018

the HDAC10 protein has proven to be an invaluable asset in protein electron microscopy structure analysis.

Q&As

How does HDAC10 impact neuronal function?

HDAC10 may influence neuronal function by regulating the acetylation status of proteins involved in synaptic plasticity and neurodevelopment.

How does HDAC10 influence immune response in cancer?

HDAC10 may affect the immune response by modulating the expression of genes involved in immune regulation, making it a potential target for immunotherapy.

What are the specific clinical applications of HDAC10 in cancer treatment?

HDAC10 inhibitors are being explored as potential anti-cancer agents, as they could help regulate gene expression and inhibit the growth of cancer cells.

Are there any ongoing clinical trials targeting HDAC10 in cancer therapy?

Several clinical trials are investigating the efficacy and safety of HDAC10 inhibitors in different cancer types.

Is HDAC10 exclusively associated with cancer, or does it have relevance in other diseases?

While its primary focus is often on cancer, HDAC10 has also been implicated in other diseases, including neurological disorders.