Active Recombinant Human IDUA, His-tagged
Cat.No. : | IDUA-27H |
Product Overview : | Recombinant human IDUA (Ala26Pro653), fused with 10*his tag at C-terminal, was expressed in Mouse NSO Cells, 71 kDa . |
- Specification
- Gene Information
- Related Products
Cat. No. : | IDUA-27H |
Description : | α-L-Iduronidase encoded by the IDUA gene is an important enzyme required for the lysosomal degradation of glycosaminoglycans (GAGs). It hydrolyzes the non-reducing terminal α-L-iduronic acid residues in GAGs including dermatan sulfate and heparan sulfate. Mutations in IDUA that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). MPS I causes progressive cellular, tissue and organ damage, and several clinical studies using enzyme replacement therapy have shown promising benefit. |
Source : | Mammalian cells |
Species : | Human |
Form : | Supplied as a 0.2 μm filtered solution in Sodium Acetate and NaCl. |
Purity : | > 95% as determined by SDS-PAGE |
Activity : | Measured by its ability to cleave a fluorogenic substrate, 4Methylumbelliferyl αLiduronide. The specific activity is >7,500 pmol/min/µg. |
EndotoxinLevel : | <1.0 EU per 1 μg of the protein by the LAL method |
Storage : | 6 months from date of receipt, 20 to 70 °C as supplied; 3 months, 20 to 70 °C under sterile conditions after opening. |
OfficialSymbol : | IDUA |
Gene Name : | IDUA iduronidase, alpha-L- [ Homo sapiens ] |
Synonyms : | IDUA;iduronidase, alpha-L-; IDA; MPS1; Alpha-L-iduronidase; EC 3.2.1.76; OTTHUMP000002173092; OTTHUMP00000112666; α-L-iduronidase precursor |
Gene ID : | 3425 |
mRNA Refseq : | NM_000203 |
Protein Refseq : | NP_000194 |
MIM : | 252800 |
UniProt ID : | P35475 |
Chromosome Location : | 4p16.3 |
Pathway : | Dermatan sulfatedegradation; Dermatan sulfate degradation; Glycosaminoglycan degradation; Glycosaminoglycan degradation; Heparan sulfate degradation; Heparan sulfatedegradation; Lysosome; Metabolic pathways |
Function : | L-iduronidaseactivity; cation binding |
Products Types
◆ Recombinant Protein | ||
IDUA-196H | Recombinant Human IDUA Protein, His-tagged | +Inquiry |
IDUA-995H | Recombinant Human IDUA Protein, MYC/DDK-tagged | +Inquiry |
Idua-1215M | Recombinant Mouse Idua Protein, MYC/DDK-tagged | +Inquiry |
IDUA-1421H | Recombinant Human IDUA Protein (28-653 aa), His-tagged | +Inquiry |
IDUA-1140H | Recombinant Human IDUA Protein, His (Fc)-Avi-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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