Active Recombinant Human IL17F protein
| Cat.No. : | IL17F-129H |
| Product Overview : | Recombinant Human IL17F was expressed in E. coli. |
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| Species : | Human |
| Source : | E.coli |
| Tag : | Non |
| Description : | Interleukin 17F is a disulfide-linked homodimeric protein belonging to the IL-17 family of proinflammatory cytokines. Members belonging to this family share conserved features of cysteine-knot structures but differ in their N-terminal regions. The T-helper cell produced IL-17 family is inducible by IL15 and IL23, and IL17F induces T-cell and PBMC activation and proliferation. It also performs cartilage matrix turnover and angiogenesis prevention. Out of the IL-17 family, IL17F is the most homologous to IL17 and dimerizes in a way similar to that of nerve growth factors (NGF) and other neurotrophins. |
| Form : | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA (with BSA as a carrier protein) |
| Bio-activity : | The ED50 is 8.0-40.0ng/mL as determined by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. |
| Molecular Mass : | 15.2 kDa |
| Endotoxin : | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Purity : | >95% |
| Applications : | Cell Assay |
| Storage : | The lyophilized protein is stable for at least one year from date of receipt at -70 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at 2 centigrade - 8 centigrade for one month, or at -20 centigrade for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Reconstitution : | Reconstitute in sterile 4mM HCl at 25μg/mL (containing at least 0.1% human or bovine serum albumin) |
| Gene Name | IL17F interleukin 17F [ Homo sapiens ] |
| Official Symbol | IL17F |
| Synonyms | IL17F; interleukin 17F; interleukin-17F; IL 17F; ML 1; ML1; IL-24; cytokine ML-1; mutant IL-17F; interleukin-24; ML-1; CANDF6; IL-17F; |
| Gene ID | 112744 |
| mRNA Refseq | NM_052872 |
| Protein Refseq | NP_443104 |
| MIM | 606496 |
| UniProt ID | Q96PD4 |
| Chromosome Location | 6p12 |
| Pathway | IL23-mediated signaling events, organism-specific biosystem; |
| Function | cytokine activity; cytokine binding; protein homodimerization activity; |
Not For Human Consumption!
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