Il17f
-
Official Full Name
interleukin 17F -
Overview
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] -
Synonyms
IL17F;interleukin 17F;ML1;ML-1;CANDF6;IL-17F;interleukin-17F;cytokine ML-1
Recombinant Proteins
- Human
- Rabbit
- Rat
- Mouse
- Cynomolgus
- Rhesus macaque
- Bovine
- Chicken
- HEK293
- E.coli
- Insect Cells
- Yeast
- CHO
- Mammalian Cells
- Human Cells
- His
- Non
- Fc
- GST
- Myc
- Avi
Involved Pathway
Il17f involved in several pathways and played different roles in them. We selected most pathways Il17f participated on our site, such as IL17 signaling pathway,IL23-mediated signaling events,Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with Il17f were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IL23-mediated signaling events | IL24,IL23R |
| IL17 signaling pathway | IL17C,TRAF3IP2,IL17RE,IL17RC |
| Inflammatory bowel disease (IBD) | IL1B,HLA-DRB4,TNF,MAF,STAT6,TLR2,HLA-DRB3,IL4,H2-AA,IL13 |
Protein Function
Il17f has several biochemical functions, for example, cytokine activity,cytokine binding,cytokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il17f itself. We selected most functions Il17f had, and list some proteins which have the same functions with Il17f. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine binding | NRP2,CD74,CXCR4,Fzd4,IFNGR1,CSF1R,CNTFR,GBP1,IL31RA,NOG |
| cytokine activity | BMP15,TNFB,IL7,TXLNA,BMP4,BMP7A,INHBA,TNFSF13,IL3,CCL20A.3 |
| cytokine receptor binding | IFN-a,IL17A/F1,IL15L,IFNW1,IL15,IFNA21,IL17B,IL17A/F2,IFNA13,MIF |
| protein homodimerization activity | CARD9,CASQ2,ATPIF1A,PLCB1,PGCP,SDS,ADIPOQ,PRKG2,USF1,HOGA1 |
| protein binding | TEX13A,C5orf24,MAP1LC3C,CCDC59,ARMC9,CTCFL,FYCO1,ATL2,CDK5RAP3,MAGEA2 |
Interacting Protein
Il17f has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il17f here. Most of them are supplied by our site. Hope this information will be useful for your research of Il17f.
FLJ13057
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References
- McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
- Thompson-Crispi, KA; Sargolzaei, M; et al. A genome-wide association study of immune response traits in Canadian Holstein cattle. BMC GENOMICS 15:-(2014).
