Active Recombinant Human il2, MIgG2a Fc-tagged, mutant
Cat.No. : | IL2-168H |
Product Overview : | The extracellular domain of mouse IL-2 (NP_032392.1)(Ala21-Gln169) is fused to the N-terminus of the Fc portion of a mutant mouse IgG2a was expressed in CHO cell. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and Blymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also sharedby interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic,which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeteddisruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential roleof this gene in the immune response to antigenic stimuli |
Source : | NS1 cells |
Species : | Mouse |
Tag : | MIgG2a Fc-tagged, mutant |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured using CTLL-s indicator cells. Specific Activity: 1-1.5 x106 Units/mg*. |
Molecular Mass : | 46KDa (monomer) |
AA Sequence : | Ala21-Gln169 |
Endotoxin : | <0.06 eu/μg as determined by lal>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | Il2 interleukin 2 [ Mus musculus ] |
Official Symbol : | IL2 |
Synonyms : | IL2; interleukin 2; interleukin-2; TCGF; T-cell growth factor; Il-2; |
Gene ID : | 16183 |
mRNA Refseq : | NM_008366 |
Protein Refseq : | NP_032392 |
Pathway : | Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; |
Function : | carbohydrate binding; cytokine activity; cytokine activity; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; interleukin-2 receptor binding; kappa-type opioid receptor binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionIL2 promotes the formation of memory T-cells.
IL2 has a pro-tumorigenic role in the tumor microenvironment.
IL2 synergizes with IL-12 in a mixed cytokine environment.
IL2 upregulates the expression of PD-1 checkpoint inhibitors.
IL2 is rapidly internalized by activated T-cells.
IL2 induces M1 macrophage polarization.
IL2 increases blood-brain barrier permeability.
IL2's affinity for its receptor decreases under hypoxic conditions.
IL2's bioactivity is enhanced by glycosylation.
IL2 promotes the differentiation of Th17 cells.
Customer Reviews (3)
Write a reviewPotent in T-cell activation.
Suitable for cytokine assays.
High stability.
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