Active Recombinant Human IL20RA protein, Fc-tagged

• Cat.No.: IL20RA-219H
• Product Overview: Recombinant Human IL20RA protein(Val 30 - Lys 250), fused with Fc tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally trehalose is added as protectant before lyophilization.
• Bio-activity: Human IL-20, His Tag immobilized on CM5 Chip can bind Human IL-20 R alpha, Fc Tag with an affinity constant of 4.42 μM as determined in a SPR assay (Biacore 8K).
• Molecular Mass: This protein carries a human IgG1 Fc tag at the C-terminus.The protein has a calculated MW of 51.7 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Proteinlength: Val30-Lys250
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.>90% as determined by SEC-MALS.
• Storage: For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
  -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
• Protein length: Val30-Lys250

Gene Information

• Gene Name: IL20RA interleukin 20 receptor, alpha [ Homo sapiens ]
• Official Symbol: IL20RA
• Synonyms: IL20RA; interleukin 20 receptor, alpha; interleukin-20 receptor subunit alpha; IL 20R1; ZCYTOR7; CRF2-8; IL-20RA; IL-20R-alpha; interleukin-20 receptor I; IL-20 receptor subunit alpha; class II cytokine receptor ZCYTOR7; cytokine receptor class-II member 8; cytokine receptor family 2 member 8; IL-20R1; FLJ40993
• Gene ID: 53832
• mRNA Refseq: NM_014432
• Protein Refseq: NP_055247
• MIM: 605620
• UniProt ID: Q9UHF4

Reviews

07/12/2021

Good for signaling studies.

10/13/2017

High specificity.

10/03/2016

Effective in skin models.

Q&As

What is the impact of IL20RA on cytokine secretion?

IL20RA increases IL-17 and IL-22 production.

Does IL20RA expression correlate with disease severity in psoriasis?

IL20RA expression correlates with disease severity in psoriasis.

What is IL20RA's role in autoimmune diseases?

IL20RA is implicated in autoimmune diseases like psoriasis.

How does IL20RA modulate skin inflammation?

IL20RA modulates skin inflammation by activating keratinocytes.

How does IL20RA expression change in cancerous tissues?

IL20RA expression is upregulated in melanoma.

How does IL20RA influence the JAK-STAT signaling pathway?

IL20RA activates the JAK-STAT signaling pathway.

Does IL20RA interact with other interleukin receptors?

IL20RA interacts with IL-20 and IL-24 receptors.

How does IL20RA affect T-cell differentiation?

IL20RA induces Th17 cell differentiation.

Does IL20RA have a role in cell migration?

IL20RA promotes keratinocyte migration.

What post-translational modifications occur on IL20RA?

IL20RA undergoes phosphorylation.