Active Recombinant Human Il23A, MIgG2a Fc-tagged

Cat.No. : Il23A-002H
Product Overview : The human IL-23 complex composed of the IL23a subunit(NP_057668.1) (Met1-Pro189) and the IL12b subunit(NP_002178.2)(Ile23-Ser328) is fused through a polypeptide linker to the Fc region of mouse IgG2a was expressed in CHO cell.
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Description : This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this proteinand the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12(IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4,and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) Tcells, IL23 preferentially acts on memory CD4(+) T cells
Source : CHO cell
Species : Human
Tag : MIgG2a Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.
Molecular Mass : 81KDa (monomer)
AA Sequence : The human IL-23 complex composed of the IL23a subunit(NP_057668.1) (Met1-Pro189) and the IL12b subunit(NP_002178.2)(Ile23-Ser328) is fused through a polypeptide linker to the Fc region of mouse IgG2a.
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : >98%, by SDS-PAGE under reducing conditions
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Protein length : Met1-Pro189;Ile23-Ser328
Gene Name : IL23A interleukin 23, alpha subunit p19 [ Homo sapiens ]
Official Symbol : IL23A
Synonyms : IL23A; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; IL 23; IL 23A; IL23P19; interleukin six; G CSF related factor; P19; SGRF; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six, G-CSF related factor; IL-23; IL-23A; MGC79388;
Gene ID : 51561
mRNA Refseq : NM_016584
Protein Refseq : NP_057668
MIM : 605580
UniProt ID : Q9NPF7
Chromosome Location : 12q13.13
Pathway : ATF-2 transcription factor network, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; Pertussis, organism-specific biosystem;
Function : cytokine activity; contributes_to interleukin-23 receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
04/18/2020

    Coupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.

    12/02/2016

      Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.

      02/25/2016

        Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.

        Q&As (6)

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        Is this bioactive cyno IL-23 heterodimer (p19/p40) or just the cyno IL-23p19 subunit? 02/01/2023

        Please inquiry our product manager with specific product.

        Are there any FDA-approved drugs targeting IL23A? 12/22/2021

        Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.

        Is IL23A involved in the regulation of adaptive or innate immunity? 08/23/2018

        IL23A primarily plays a role in regulating the adaptive immune response.

        How is IL23A linked to the pathogenesis of ankylosing spondylitis? 01/25/2018

        IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.

        How does IL23A contribute to rheumatoid arthritis? 09/01/2017

        In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.

        How is IL23A involved in inflammatory bowel diseases like Crohn's disease? 07/03/2016

        IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.

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