Active Recombinant Human IL2RB protein(Met1-Asp239)
Cat.No. : | IL2RB-783H |
Product Overview : | Recombinant Human IL2RB protein(NP_000869.1)(Met1-Asp239) was expressed in HEK293. |
Availability | February 11, 2025 |
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similar : | IL2RB |
Alias : | IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75; |
Source : | HEK293 |
Species : | Human |
Conjugate : | N/A |
Tag : | Non |
Protein length : | Met1-Asp239 |
Form : | Lyophilized from sterile 100mM NaCl, 50mM Tris, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Bioactivity : | Measured by its ability to inhibit IL15-dependent proliferation of MO7e human megakaryocytic leukemic cells in the presence of 4.0 ng/mL of recombinant human IL-15. The ED50 for this effect is 1-4μg/mL. |
MolecularMass : | The mature recombinant human IL2 Rβ consists of 219 amino acids and has a predicted molecular mass of 25.2 kDa. As a result of glycosylation, the rh IL2 Rβ migrates as an approximately 40 kDa protein in SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 90 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
GeneName : | IL2RB interleukin 2 receptor, beta [ Homo sapiens ] |
GeneNameWeblink : | 3560 |
OfficialSymbol : | IL2RB |
OfficialSymbolWeblink : | 3560 |
GeneIDWeblink : | 3560 |
mRNARefseq : | NM_000878 |
mRNARefseqWeblink : | NM_000878.2 |
ProteinRefseqWeblink : | NP_000869.1 |
MIMWeblink : | 146710 |
UniProtID : | P14784 |
UniProtIDWeblink : | P14784 |
Synonyms : | IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75; |
Gene ID : | 3560 |
MIM : | 146710 |
Synonyms : | IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75; |
Gene ID : | 3560 |
MIM : | 146710 |
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◆ Lysates | ||
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewImmunogenicity is very weak and does not cause an immune response.
Detection method is very sensitive and can detect trace amounts of protein.
Preparation process is very simple and can be easily prepared.
Q&As (6)
Ask a questionIt is an artificial protein prepared by genetic engineering techniques that can mimic the natural IL-2R beta subunit and is used to explore how to treat cancer and autoimmune diseases by regulating the IL-2 signaling pathway.
There has shown good therapeutic effect in the treatment of some tumors (such as lung cancer, melanoma, etc.), but the specific efficacy varies with the patient's condition, treatment timing and other factors.
This protein can simulate the natural IL-2R beta subunit and participate in the IL-2 signaling pathway, thereby enhancing the body's immunity.
IL2RB is associated with a variety of cancers (such as gastric cancer, lung cancer, liver cancer, lymphoma, etc.) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, etc.).
IL2RB can be used as a new therapeutic method, but it does not mean that it can replace traditional therapeutic methods. In the course of specific treatment, different treatment methods should be considered according to the condition.
IL2RB may produce some side effects, including fever, headache, nausea, vomiting, etc., but the incidence of different side effects is low.
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