Active Recombinant Human Interleukin 17F, HIgG1 Fc-tagged
|Product Overview :||The extracellular domain of human IL-17F (AAH70124.1)(Arg31-Gln163) is fused to the N-terminus of the Fc region of a human IgG1 was expressed in CHO cell.|
- Gene Information
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|Description :||The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.|
|Source :||CHO cell|
|Tag :||HIgG1 Fc-tagged|
|Form :||Lyophilized from 0.2μm-filtered solution in PBS.|
|Bio-activity :||Measured by its ability to induce IL-6 secretion.|
|Molecular Mass :||41KDa (monomer)|
|AA Sequence :||Arg31-Gln163|
|Endotoxin :||<0.06 eu/μg as determined by lal test.>0.06>|
|Purity :||>98%, by SDS-PAGE under reducing conditions.|
|Stability :||Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.|
|Reconstitution :||Reconstitute at 100μg/ml in sterile PBS.|
|Warning :||Avoid freeze/thaw cycles.|
|Gene Name :||IL17F interleukin 17F [ Homo sapiens ]|
|Official Symbol :||IL17F|
|Synonyms :||IL17F; interleukin 17F; interleukin-17F; IL 17F; ML 1; ML1; IL-24; cytokine ML-1; mutant IL-17F; interleukin-24; ML-1; CANDF6; IL-17F;|
|Gene ID :||112744|
|mRNA Refseq :||NM_052872|
|Protein Refseq :||NP_443104|
|UniProt ID :||Q96PD4|
|Chromosome Location :||6p12|
|Pathway :||IL23-mediated signaling events, organism-specific biosystem;|
|Function :||cytokine activity; cytokine binding; protein homodimerization activity;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Tumor xenografts, immune cell infiltration analysis, and therapeutic antibody testing assess IL17F's role in cancer.
Neutrophil chemotaxis assays, in vivo neutrophil tracking, and immune cell activation analysis explore IL17F's impact on neutrophil functions.
Genetic knockout models, functional assays, and gene expression analyses distinguish IL17F's unique roles.
Microbiota composition analysis, germ-free models, and immune cell profiling investigate IL17F-microbiota interactions.
Animal disease models, patient samples, and immunological assays elucidate IL17F's contribution to autoimmune diseases.
Co-immunoprecipitation, fluorescence resonance energy transfer (FRET), and pathway-specific assays elucidate IL17F's heterodimerization and signaling.
Comparative cytokine profiling, inflammatory assays, and pathway analysis dissect IL17F's interplay with other immune mediators.
Allergen challenges, inflammatory disease models, and gene expression profiling probe IL17F's involvement in chronic conditions.
Epithelial barrier permeability assays, tissue section analysis, and cell culture models study IL17F's effects on barrier integrity.
Wound healing assays, tissue regeneration models, and histological analyses examine IL17F's effects on tissue repair.
Customer Reviews (3)Write a review
High specificity. -
Good for receptor studies. -
Potent in anti-bacterial assays. -
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