Active Recombinant Human Interleukin 2
Cat.No. : | IL2-116H |
Product Overview : | Recombinant Human interleukin 2 protein sequence (containing the signal peptide sequence, and the mature human Interleukin 2 sequence) was expressed in modifiedhuman 293 cells. |
Availability | February 11, 2025 |
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Cat. No. : | IL2-116H |
Description : | Interleukin-2 (IL-2) is a pleotropic glycoprotein that mediates the production of regulatory T cells and promotes T cell dependent tolerance. Additionally, IL-2 promotes the proliferation of antigen-activated T lymphocytes, facilitates the cytolytic activity of natural killer (NK) cells and stimulates anti-tumor activity in monocytes by inducing synthesis of GM-CSF, IL-1b and IL-6. IL-2 also promotes the proliferation of large granular lymphocytes and the growth and differentiation of mitogen activated B lymphocytes in vitro. |
Source : | Human 293 cells. |
Amino Acid Sequence : | APTSSSTK KTQLQL EHLLLDLQ MILNGIN NYKNPKLT RMLTFKFY MPKKATEL KHLQCLEE ELKPLEEVL NLAQSK NFHLRPRD LISNINVIVLELKG SETTF MCEY ADE TATIVEFL NRWITFCQSIISTLT. |
Molecular Mass : | IL-2 migrates as a band between 15 and 18 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation. This compares with the unmodified IL-2 that has a predicted molecular mass of 15.4 kDa. |
PI : | IL-2 separates into a number of isoforms with a pI between 6.0 and 7.4 in 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified IL-2 that has a predicted pI of 7.05. |
% Carbohydrate : | Purified IL-2 consists of 0-15% carbohydrate by weight. |
Glycosylation : | IL-2 has O-linked oligosaccharides. |
Purity : | >95%, as determined by SDS-PAGE and visualized by silver stain. |
Formulation : | When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
Reconstitution : | It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
Storage : | Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended. |
Activity : | The ED50of IL-2 is typically 0.15- 0.25 ng/ml as measured in a cell proliferation assay using the IL-2 dependent murine CTLL-2 T cell line. |
Tag : | Non |
Gene Name : | IL2 interleukin 2 [ Homo sapiens ] |
Synonyms : | IL2; interleukin 2; IL-2; TCGF; lymphokine; T cell growth factor; aldesleukin; interleukin-2; involved in regulation of T-cell clonal expansion; Aldesleukin; interleukin 2; T cell growth factor |
Gene ID : | 3558 |
mRNA Refseq : | NM_000586 |
Protein Refseq : | NP_000577 |
MIM : | 147680 |
UniProt ID : | P60568 |
Chromosome Location : | 22q13.1 |
Pathway : | Cytokine-cytokine receptor interaction; Endocytosis; Jak-STAT signaling pathway |
Function : | interleukin-2 receptor activity; receptor activity |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewPotent in T-cell activation.
Suitable for cytokine assays.
High stability.
Q&As (10)
Ask a questionIL2 promotes the formation of memory T-cells.
IL2 has a pro-tumorigenic role in the tumor microenvironment.
IL2 synergizes with IL-12 in a mixed cytokine environment.
IL2 upregulates the expression of PD-1 checkpoint inhibitors.
IL2 is rapidly internalized by activated T-cells.
IL2 induces M1 macrophage polarization.
IL2 increases blood-brain barrier permeability.
IL2's affinity for its receptor decreases under hypoxic conditions.
IL2's bioactivity is enhanced by glycosylation.
IL2 promotes the differentiation of Th17 cells.
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