Active Recombinant Human Killer Cell Lectin-Like Receptor Subfamily F, Member 1, Fc-tagged
Cat.No. : | KLRF1-5672H |
Product Overview : | Recombinant Human KLRF1protein was expressed in Murine myeloma cell line with the Fc part of humanIgG1 Pro100-Lys330 (N-terminus) and Val66-Tyr231 (C-terminus). |
- Specification
- Gene Information
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Cat. No. : | KLRF1-5672H |
Description : | KLRF1 is an 80 kDatype II transmembrane, homodimeric, activating coreceptor expressedexclusively on the surface of NK cells. Human KLRF1, a member of the C-typelectin family of proteins, is 231 aa in length with a 38 amino acid (aa)cytoplasmic region, a 21 aa transmembrane region, and a 172 aa extracellulardomain (ECD). The ECD contains the C-type lectin like domain (aa 114-230) andfour potential sites of N-linked glycosylation. Multiple splicing variantsproduce four isoforms for KLRF1. |
Source : | Mammalian cells |
Form : | Lyophilized from a0.2 μm filtered solution in PBS. |
N-terminalSequence : | Met |
Molecular Weight : | 45.8 kDa |
Activity : | Measuredby the ability of the immobilized protein to support the adhesion of U937human histiocytic lymphoma cells. Welte, S. et al. (2006) Nat. Immunol. 7:12.rhKLRF1/Fc Chimera, immobilized at 5 μg/mL (100 μL/well), can induce greaterthan 40% of U937 cell adhesion. |
Endotoxin Level : | <1.0 EUper 1 μg of the protein by the LAL method. |
SDS-PAGE : | 59-62kDa, reducing conditions. |
Purity : | >90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | 100μg/mL in sterile PBS |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution. |
Gene Name : | KLRF1 killer cell lectin-likereceptor subfamily F, member 1 [ Homo sapiens ] |
Official Symbol : | KLRF1 |
Synonyms : | KLRF1; killer celllectin-like receptor subfamily F, member 1; NKp80; CLEC5C; MGC119907;MGC119908; MGC119909; lectin-like receptor F1; activating coreceptor NKp80;killer cell lectin-like receptor F1; C-type lectin domain family 5 member C;killer cell lectin-like receptor subfamily F member 1; ML;OTTHUMP00000238675; OTTHUMP00000238676; OTTHUMP00000238678 |
Gene ID : | 51348 |
mRNA Refseq : | NM_016523 |
Protein Refseq : | NP_057607 |
MIM : | 605029 |
UniProt ID : | Q9NZS2 |
Chromosome Location : | 12p13.31 |
Function : | MHC class I receptoractivity; binding; receptor activity; sugar binding; transmembrane signalingreceptor activity |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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