Active Recombinant Human KMT5A Protein, His-tagged

• Cat.No.: KMT5A-139H
• Product Overview: Active recombinant N-terminal hexahistidine-tagged human KMT5A protein (190-352) was purified from E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 190-352
• Description: The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation.
• Bio-activity: Qualitative biological assay-reduces uptake of LDL-DyLight™ by > 30% in Huh7 cells at concentrations above 5 μg/mL.
  Activity was determined using 50 μM substrate peptide (AKRHRKVLRD) at 37 centigrade using a Methyltransferase Colorimetric Assay Kit.
• Molecular Mass: 21.1 kDa
• Purity: ≥90% as determined by SDS-PAGE
• Stability: ≥ 6 months
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM sodium phosphate, pH 7.2, with 100 mM sodium chloride and 20% glycerol

Gene Information

• Gene Name: KMT5A lysine methyltransferase 5A [ Homo sapiens (human) ]
• Official Symbol: KMT5A
• Synonyms: KMT5A; lysine methyltransferase 5A; SET8; SET07; SETD8; PR-Set7; PR/SET07; N-lysine methyltransferase KMT5A; H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; H4-K20-specific histone methyltransferase; H4K20-specific histone methyltransferase splice variant Set8b; N-lysine methyltransferase SETD8; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; SET domain containing (lysine methyltransferase) 8; SET domain-containing protein 8; histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; lysine (K)-specific methyltransferase 5A; lysine N-methyltransferase 5A; lysine-specific methylase 5A; EC 2.1.1.361
• Gene ID: 387893
• mRNA Refseq: NM_020382
• Protein Refseq: NP_065115
• MIM: 607240
• UniProt ID: Q9NQR1