| Species : |
Human |
| Source : |
E.coli |
| Tag : |
His |
| Protein Length : |
20-96 aa |
| Description : |
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. |
| Form : |
Lyophilized from a 0.22 μm filtered solution of PBS, 6-8% Trehalose, pH 7.4. |
| Bio-activity : |
Measured in a cell proliferation assay using HT-29 cells. The ED50 for this effect is 61.07 ng/mL, corresponding to a specific activity is 1.637×10^4 Unit/mg. |
| Molecular Mass : |
13 kDa |
| AASequence : |
YESHESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYF |
| Endotoxin : |
< 1 EU/μg by LAL |
| Storage : |
Stored at -20 centigrade for 2 years from date of receipt. After reconstitution, it is stable at 4 centigrade for 1 week or -20 centigrade for longer (with carrier protein). It is recommended to freeze aliquots at -20 or -80 centigrade for extended storage. |
| Shipping : |
Room temperature in continental US; may vary elsewhere. |
| Reconstitution : |
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. |
