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Active Recombinant Human MSLN Protein, His-tagged, Alexa Fluor® 647 conjugated

Cat.No. : MSLN-16H
Product Overview : Recombinant human Alexa Fluor® 647 conjugated Mesothelin (Glu296-Gly580) with a His tag at C-Terminal was expressed in mouse myeloma cell line.
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Description : This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Source : Mouse myeloma cell line
Species : Human
Tag : His
Form : Labeled with Alexa Fluor® 647 via amine.
Excitation Wavelength: 650 nm
Emission Wavelength: 668 nm
Bio-activity : Measured by flow cytometry for its ability to bind anti-human Mesothelin Monoclonal Antibody conjugated beads. The concentration of Recombinant Human Mesothelin C-Terminal (aa 296-580) His-tag Alexa Fluor® 647 that produces 50% of the binding response is 1.00-20.0 ng/mL.
Molecular Mass : 33 kDa
N-terminal Sequence Analysis : Glu296
Endotoxin : <1.0 EU/μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Protect from light. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
6 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after opening.
3 months, -20 to -70 centigrade under sterile conditions after opening.
Storage Buffer : Supplied as a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping : The product is shipped with dry ice or equivalent.
Gene Name : MSLN mesothelin [ Homo sapiens (human) ]
Official Symbol : MSLN
Synonyms : MSLN; mesothelin; MPF; SMRP; mesothelin; CAK1 antigen; megakaryocyte potentiating factor; pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein
Gene ID : 10232
mRNA Refseq : BC009272
Protein Refseq : AAH09272
MIM : 601051
UniProt ID : Q13421

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of MSLN in normal tissues? 12/07/2022

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells? 03/19/2022

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed? 03/28/2021

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment? 02/25/2020

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings? 10/07/2019

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients? 11/23/2018

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis? 11/07/2018

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.

Customer Reviews (3)

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Reviews
05/22/2022

    Very satisfied, great product.

    03/06/2022

      Product is high-quality.

      09/30/2021

        Excellent for experiments, reliable.

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