Active Recombinant Human Neurotrophin 3

Cat.No. : NTF3-044H
Product Overview : Recombinant human NT-3 was expressed in E. coli and purified by SDS PAGE and HPLC, 13.6 KDa.
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Cat. No. : NTF3-044H
Description : NT-3 is a neurotrophic factor structurally related to beta-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, Mouse and rat NT-3 are identical.
Source : Human
Host : E.coli
Form : Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Allow to set for at least 30 minutes, mix well.
Purity : > 98% pure by SDS PAGE and HPLC
Sequence : Region of NT3 protein corresponding to amino acids MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT.
Molecular Mass : 13.6 kDa
Applications : Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
Endotoxin Levels : Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Bioactivity : The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
Storage : Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
SDS-PAGE:
Gene Name : NTF3 neurotrophin 3 [ Homo sapiens ]
Official Symbol : NTF3
Synonyms : neurotrophin 3; NT3; HDNF; NGF2; NGF-2; MGC129711; NTF3; NT-3; Nerve growth factor 2; Neurotrophic factor
Gene ID : 4908
mRNA Refseq : NM_001102654
Protein Refseq : NP_001096124
MIM : 162660
UniProt ID : P20783
Chromosome Location : 12p13
Pathway : MAPK signaling pathway; Neurotrophic factor-mediated Trk receptor signaling; Neurotrophin signaling pathway; Trk receptor signaling mediated by the MAPK pathway; p75(NTR)-mediated signaling
Function : growth factor activity; nerve growth factor binding; neurotrophin receptor binding; receptor binding

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