Active Recombinant Human NTRK3 Protein, His-tagged, FITC conjugated
Cat.No. : | NTRK3-160HF |
Product Overview : | A DNA sequence encoding the extracellular domain (Met 1-Asp 428) of human TrkC (FITC conjugated) was expressed with a C-terminal polyhistide tag. |
Availability | February 16, 2025 |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
- Download
Description : | NT-3 growth factor receptor is also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC/NTRK3 is widely expressed in the developing and adult nervous system. In later embryonic development, TrkC/NTRK3 is expressed in various structures of the CNS including the caudate-putamen, septal nuclei, cerebellum, and brainstem. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. In the PNS, The trkC hybridization appears to correlate, both temporally and spatially, with the outgrowth of axons toward their peripheral targets. TrkC/NTRK3 is widely expressed in the three identified branches of the mammalian nervous system and appears to correlate with the expression of NT-3, its cognate ligand. The apparent colocalization of trkC transcripts with NT-3 raises the possibility this neurotrophin exerts its trophic effects by a paracrine and/or autocrine mechanism. Signaling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in the TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas, and other cancers. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized |
Bio-activity : | Immobilized human Trkc-His at 10 μg/mL (100 μL/well) can bind biotinylated human NT3, The EC50 of biotinylated human NT3 is 0.03-0.07 μg/mL. |
Molecular Mass : | The recombinant human TrkC consists of 408 amino acids and has a calculated molecular mass of 46.1 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 80-90 kDa protein in SDS-PAGE under reducing conditions. |
Protein length : | Met1-Asp428 |
Endotoxin : | < 1.0 EU/ μg of the protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with FITC via amines Excitation source: 488 nm spectral line, argon-ion laser Excitation Wavelength: 488 nm Emission Wavelength: 535 nm |
Storage : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/ml. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | NTRK3 neurotrophic tyrosine kinase, receptor, type 3 [ Homo sapiens ] |
Official Symbol : | NTRK3 |
Synonyms : | TRKC; GP145-TrkC; gp145(trkC) |
Gene ID : | 4916 |
mRNA Refseq : | NM_001007156 |
Protein Refseq : | NP_001007157 |
MIM : | 191316 |
UniProt ID : | Q16288 |
Products Types
◆ Recombinant Protein | ||
Ntrk3-4524M | Recombinant Mouse Ntrk3 Protein, Myc/DDK-tagged | +Inquiry |
Ntrk3-035M | Recombinant Mouse Ntrk3 Protein, His-tagged | +Inquiry |
NTRK3-2938R | Recombinant Rhesus Macaque NTRK3 Protein, His (Fc)-Avi-tagged | +Inquiry |
NTRK3-159H | Active Recombinant Human NTRK3 protein(Met1-Asp428), His&hFc-tagged | +Inquiry |
NTRK3-4468H | Recombinant Human NTRK3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
NTRK3-2825HCL | Recombinant Human NTRK3 cell lysate | +Inquiry |
NTRK3-2583MCL | Recombinant Mouse NTRK3 cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All NTRK3 Products
Required fields are marked with *
My Review for All NTRK3 Products
Required fields are marked with *
0
Inquiry Basket