Active Recombinant Full Length Human PADI2 Protein, GST tagged

• Cat.No.: PADI2-12HFL
• Product Overview: Recombinant full-length human PAD2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Description: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
• Molecular Mass: 102 kDa
• Bio-activity: 1.0 nmol/min/mg
• Purity: > 90%
• Stability: One year at –70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade for up to one year. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Storage Buffer: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, and 25% glycerol.
• Concentration: 0.1 μg/μL
• Shipping: Dry ice

Gene Information

• Gene Name: PADI2 peptidyl arginine deiminase, type II [ Homo sapiens (human) ]
• Official Symbol: PADI2
• Synonyms: PADI2; peptidyl arginine deiminase, type II; protein-arginine deiminase type-2; KIAA0994; PDI2; protein arginine deiminase; peptidylarginine deiminase II; peptidlyarginine deiminase type II; protein-arginine deiminase type II; PAD2; PAD-H19
• Gene ID: 11240
• mRNA Refseq: NM_007365
• Protein Refseq: NP_031391
• MIM: 607935
• UniProt ID: Q9Y2J8