Active Recombinant Human PDCD1 Protein

• Cat.No.: PDCD1-01H
• Product Overview: Recombinant Human PDCD1 Protein was expressed in HEK293 cell

Specification

• Description: Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
• Source: HEK293
• Species: Human
• Form: Lyophilized
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Molecular Mass: Expected molecular weight ~16 kD, observed molecular weight 30 kD in SDS-PAGE due to glycosylation of the protein.
• Protein length: Protein fragment
• AA Sequence: LDSPDRPWNP PTFSPALLVV TEGDNATFTC SFSNTSESFV LNWYRMSPSN QTDKLAAFPE DRSQPGQDCR FRVTQLPNGR DFHMSVVRAR RNDSGTYLCG AISLAPKAQI KESLRAELRV TERRAEVPTA HPSPSPRPAG QFQ
• Endotoxin: < 0.010 Eu/µg
• Purity: > 95 % SDS-PAGE.
• Applications: SDS-PAGE
  Functional Studies
• Notes: FOR RESEARCH USE ONLY.NOT FOR USE IN DIAGNOSTIC PROCEDURES
• Storage: Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
  Constituent: PBS
  Lyophilized from 0.2µm-filtered solution.
  This product is an active protein and may elicit a biological response in vivo, handle with caution.
• Storage Buffer: Lyophilized from 0.2µm-filtered solution.
• Reconstitution: Reconstitute 50µg vial with 100 µl sterile water to a concentration of 0.5 mg/ml. Add 1X PBS to the desired protein concentration. PBS containing at least 0.1% BSA should be used for further dilutions.
• Shipping: Shipped at 4°C.

Gene Information

• Gene Name: PDCD1 programmed cell death 1 [ Homo sapiens (human) ]
• Official Symbol: PDCD1
• Synonyms: PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
• Gene ID: 5133
• mRNA Refseq: NM_005018.3
• Protein Refseq: NP_005009.2
• MIM: 600244
• UniProt ID: Q15116

Reviews

06/06/2021

Timely antibody validation, a valuable asset for our laboratory.

02/12/2021

Precise protein quantification, fundamental for maintaining data accuracy.

06/20/2019

Dependable peptide synthesis, accelerates our peptide-based projects effectively.

Q&As

What are the mechanisms by which PDCD1 modulates the immune response to viral infections?

PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

What are the mechanisms by which PDCD1 modulates the immune response to viral infections?

PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

What role does PDCD1 play in the development of immune tolerance?

PDCD1 helps develop immune tolerance, preventing overactive immune responses.

How does PDCD1 influence the balance between immune activation and autoimmunity?

PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer?

PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

How does PDCD1 influence the balance between immune activation and autoimmunity?

PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers?

PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer?

PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells?

PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers?

PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

What role does PDCD1 play in the development of immune tolerance?

PDCD1 helps develop immune tolerance, preventing overactive immune responses.

How do alterations in PDCD1 expression or signaling affect autoimmune disease progression?

Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells?

PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

How do alterations in PDCD1 expression or signaling affect autoimmune disease progression?

Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.