Active Recombinant Human PDCD1 Protein, MIgG2a mFc-tagged, Alexa Fluor 555 conjugated
Cat.No. : | PDCD1-031HAF555 |
Product Overview : | The Alexa Fluor 555 conjugated extracellular domain of human CD279 [PD-1] (NP_005009.2) (Leu25-Gln167) is fused to the N-terminus of the Fc region of mouse IgG2a.E351 |
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Description : | This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. |
Source : | CHO |
Species : | Human |
Tag : | mFc |
Form : | Lyophilized |
Bio-activity : | Measured by its binding ability in a functional ELISA. |
Molecular Mass : | 46 kDa (monomer) |
AA Sequence : | Leu25-Gln167 |
Endotoxin : | < 0.06 EU/ μg as determined by LAL test. |
Purity : | > 98 % by SDS-PAGE under reducing conditions. |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 555 via amines With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters. |
Stability : | Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. |
Concentration : | 100 μg/mL |
Storage Buffer : | Lyophilized from 0.2 μm filtered solution in PBS. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
Gene Name : | PDCD1 programmed cell death 1 [ Homo sapiens ] |
Official Symbol : | PDCD1 |
Synonyms : | PDCD1; programmed cell death 1; programmed cell death protein 1; CD279; PD1; protein PD-1; PD-1; SLEB2; hPD-1; hPD-l; |
Gene ID : | 5133 |
mRNA Refseq : | NM_005018 |
Protein Refseq : | NP_005009 |
MIM : | 600244 |
UniProt ID : | Q15116 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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