Active Recombinant Human PSPN Protein

• Cat.No.: PSPN-098H
• Product Overview: The mature recombinant human Persephin protein consists of 96 amino acids (61-156) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 61-156 a.a.
• Description: This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma.
• Bio-activity: Measured in a cell proliferation assay using TT human medullary thyroid cancer cells. The ED50 for this effect is 4-16 ng/mL.
• Molecular Mass: 20.5 kDa
• Product-Related Proteins: 61-156
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: PSPN persephin [ Homo sapiens (human) ]
• Official Symbol: PSPN
• Synonyms: PSPN; persephin; PSP; persephin
• Gene ID: 5623
• mRNA Refseq: NM_004158
• Protein Refseq: NP_004149
• MIM: 602921
• UniProt ID: O60542