Active Recombinant Human ROS1 (L2086F) Protein, GST tagged

• Cat.No.: ROS1-03H
• Product Overview: Recombinant human ROS1 (L2086F) (1881-end) was expressed by baculovirus in Sf9 insect cells using an N terminal GST tag. The gene accession number is NM_002944.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: ROS1: 1881-end
• Description: This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, and 25% glycerol.
• Bio-activity: 108 nmol/min/mg
• Molecular Mass: ~82 kDa
• Purity: >90%
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Stability: 1 yr at –70 centigrade from date of shipment.
• Concentration: 0.1 μg/μL
• Shipping: Dry ice
• Reference: 1. Charest, A. et al: Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer 37: 58-71, 2003. 2. Biscup, C. et al: Visualization of SHP-1-target interaction. J Cell Sci. 2004 Oct 1;117(Pt 21):5165-78. 3. Gendarme, S. et al: ROS-1 Fusions in Non-Small-Cell Lung Cancer: Evidence to Date. Curr. Oncol. 29(2):641-658, 2022.

Gene Information

• Gene Name: ROS1 ROS proto-oncogene 1, receptor tyrosine kinase [ Homo sapiens (human) ]
• Official Symbol: ROS1
• Synonyms: ROS1; c-ros oncogene 1 , receptor tyrosine kinase; v ros avian UR2 sarcoma virus oncogene homolog 1 , v ros UR2 sarcoma virus oncogene homolog 1 (avian); proto-oncogene tyrosine-protein kinase ROS; c ros 1; MCF3; ROS; proto-oncogene c-Ros; proto-oncogene c-Ros-1; c-Ros receptor tyrosine kinase; receptor tyrosine kinase c-ros oncogene 1; v-ros UR2 sarcoma virus oncogene homolog 1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; c-ros-1
• Gene ID: 6098
• mRNA Refseq: NM_002944
• Protein Refseq: NP_002935
• MIM: 165020
• UniProt ID: P08922