Active Recombinant Human SIGLEC9 Homodimer Protein, His tagged

• Cat.No.: SIGLEC9-57H
• Product Overview: Siglec 9 dimer protein contains a Siglec 9 extracellular domain (UniProt# Q9Y336) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: His
• Protein Length: 18-348 aa
• Description: Human Sialic acid-binding Ig-like lectin 9 (Siglec 9) is a member of the Siglec family, part of the immunoglobulin superfamily, and a multifunctional immune regulator. It plays an important role in the immune system, especially in regulating inflammation and immune cell activation. Siglec 9 is also known as Cluster of Differentiation 329 (CD329), CDw329, FOAP-9, and OBBP-LIKE. Siglec 9 is a Type I transmembrane protein. It contains an extracellular domain with an N-terminal V-type immunoglobulin domain (Ig domain) and two C2-type Ig domains followed by a transmembrane domain and cytoplasmic signaling domain consisting of the immunoreceptor tyrosine-based inhibitory motif (ITIM). Siglec 9 is expressed on monocytes, neutrophils, and dendritic cells. It binds sialylated glycans on cell surfaces or secreted proteins, modulating cell-cell interactions and immune responses. Siglec 9 can form homodimers on the cell surface that plays a role in ligand binding, signal transduction, and receptor clustering. Some tumors express high levels of sialic acids to engage Siglec 9 and suppress immune attacks — potential immune evasion mechanism. The interaction of sialic acids with Siglecs is associated with suppression of anti-tumor responses has made Siglecs an emerging target for cancer therapeutics.
• Molecular Mass: 88 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for Siglec 9-specific antibody binding assays. Suggested Applications: SPR & BLI for Siglec 9-specific antibody binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: SIGLEC9 sialic acid binding Ig-like lectin 9 [ Homo sapiens (human) ]
• Official Symbol: SIGLEC9
• Synonyms: SIGLEC9; sialic acid binding Ig-like lectin 9; sialic acid-binding Ig-like lectin 9; CD329; protein FOAP-9; CDw329; FOAP-9; siglec-9; OBBP-LIKE
• Gene ID: 27180
• mRNA Refseq: NM_001198558
• Protein Refseq: NP_001185487
• MIM: 605640
• UniProt ID: Q9Y336