Active Recombinant Human TGFA

• Cat.No.: TGFA-538H
• Product Overview: Human TGFA (P01135) full-elngth recombinant protein expressed in Hi-5 cells.

Specification

• Cat. No.: TGFA-538H
• Description: Transforming growth factor alpha (TGF-μ) is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects . TGFμ stimulates neural cell proliferation in the adult injured brain.
• Theoretical MW (kDa): 25
• Form: Lyophilized
• Preparation Method: Insect cell (Hi-5) expression system
• Purity: μ 98% by SDS-PAGE, μ 98% by HPLC
• Endotoxin Level: < 0.1 ng/ug
• Activity: The ED50 as determined by the ability of TGF-beta2 to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is < 0.2 ng/mL, corresponding to a specific activity of > 5 x 106 units/mg.
• Application: SDS-PAGE
• Storage Buffer: Lyophilized from sodium citrate, pH 3.5
• Storage: Store at -20°C on dry atmosphere.
• Unitprot ID: P01135
• Tag: Non
• Source: Hi-5 Insect Cells

Gene Information

• Gene Name: TGFA transforming growth factor, alpha [ Homo sapiens ]
• Official Symbol: TGFA
• Synonyms: TGFA; transforming growth factor, alpha; TFGA; protransforming growth factor alpha; transforming growth factor-alpha; TGF-alpha; EGF-like TGF; TGF type 1; ETGF
• Gene ID: 7039
• mRNA Refseq: NM_001099691
• Protein Refseq: NP_001093161
• MIM: 190170
• Chromosome Location: 2p13
• Pathway: ErbB signaling pathway; Glioma; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prostate cancer; Renal cell carcinoma
• Function: MAP kinase kinase activity; epidermal growth factor receptor binding; growth factor activity; protein binding; signal transducer activity

Reviews

05/03/2020

Swift and accurate service, essential for research success.

04/14/2020

Invaluable support for insights, a research cornerstone.

12/21/2018

Trustworthy results, supports research consistency.

Q&As

How does TGFA contribute to cell growth and proliferation?

It stimulates cell proliferation and survival, playing a key role in tissue development.

How do genetic variations in TGFA affect tissue repair?

Genetic mutations in TGFA can lead to impaired wound healing and tissue regeneration.

What is the impact of altered TGFA activity on cancer development?

Altered TGFA activity is linked with cancer progression, as it can stimulate uncontrolled cell growth.

What is the primary role of TGFA in cell signaling?

TGFA, a growth factor, is vital for activating signaling pathways that control cell growth and differentiation.

What potential therapeutic applications arise from targeting TGFA in regenerative medicine and oncology?

Targeting TGFA offers potential for treating wounds and cancer by modulating growth factor signaling.

How does TGFA interact with other growth factors and receptors?

TGFA interacts with epidermal growth factor receptors, influencing various cellular processes.

What role does TGFA play in wound healing?

TGFA is important in wound healing, promoting the regeneration of skin and other tissues.